Department of Chemistry and Nano Science and Department of Bioinspired Science (WCU), Ewha Womans University, Seoul 120-750, Korea.
Chem Soc Rev. 2012 Jan 7;41(1):52-67. doi: 10.1039/c1cs15159b. Epub 2011 Jul 28.
Due to the biological importance of amino acids, the development of optical probes for these molecules has been an active research area in recent years. This tutorial review focuses on recent contributions since the year 2000 concerning the fluorescent or colorimetric sensors for amino acids, and is organized according to their structural classification and reaction types. For reaction based chemosensors, the works are classified according to the mechanisms between sensors and amino acids, including imine formation, Michael addition, thiazinane or thiazolidine formation, cleavage of a sulfonate ester, cleavage of disulfide, metal complexes-displace coordination and others.
由于氨基酸具有重要的生物学意义,因此近年来,开发用于这些分子的光学探针一直是一个活跃的研究领域。本综述重点介绍了自 2000 年以来有关氨基酸的荧光或比色传感器的最新贡献,并根据其结构分类和反应类型进行了组织。对于基于反应的化学传感器,根据传感器与氨基酸之间的机制对工作进行了分类,包括亚胺形成、迈克尔加成、噻嗪烷或噻唑烷形成、磺酸酯的裂解、二硫键的裂解、金属配合物取代配位等。