Larson Caroline, Thomas Hannah R, Crutcher Jason, Stevens Michael C, Eigsti Inge-Marie
Department of Psychological Sciences, University of Connecticut, Storrs, CT, USA.
CT Institute for the Brain and Cognitive Sciences, Storrs, CT, USA.
Rev J Autism Dev Disord. 2025 Mar;12(1):110-137. doi: 10.1007/s40489-023-00382-6. Epub 2023 May 30.
Autism Spectrum Disorder (ASD) is a heterogeneous condition associated with differences in functional neural connectivity relative to neurotypical (NT) peers. Language-based functional connectivity represents an ideal context in which to characterize connectivity because language is heterogeneous and linked to core features in ASD, and NT language networks are well-defined. We conducted a systematic review of language-related functional connectivity literature on individuals with ASD using PubMed, PsychInfo, Scopus, ProQuest, and Google Scholar, yielding 96 studies. Language-task studies indicated local over-connectivity within the language network and global under-connectivity of language with out-of-network regions in ASD. Resting-state studies showed mixed patterns, and connectivity was associated ASD symptomology and language skills. This evidence indicates language-task elicited local over-connectivity and global under-connectivity in ASD, but not a local versus global distinction of resting-state language-related connectivity. Associations with behavior suggest that local over-connectivity and global under-connectivity characterize ASD, and heightened language-related connectivity may support social function.
自闭症谱系障碍（ASD）是一种异质性疾病，与神经典型（NT）同龄人相比，其功能性神经连接存在差异。基于语言的功能连接是表征连接性的理想背景，因为语言具有异质性且与ASD的核心特征相关联，并且NT语言网络已得到明确界定。我们使用PubMed、PsychInfo、Scopus、ProQuest和谷歌学术对关于ASD个体的语言相关功能连接文献进行了系统综述，共得到96项研究。语言任务研究表明，ASD患者的语言网络内存在局部过度连接，而语言与网络外区域的全局连接不足。静息态研究显示出混合模式，并且连接性与ASD症状学和语言技能相关。这一证据表明，语言任务在ASD中引发了局部过度连接和全局连接不足，但静息态语言相关连接不存在局部与全局的区别。与行为的关联表明，局部过度连接和全局连接不足是ASD的特征，而增强的语言相关连接可能支持社会功能。
