Institute of Psychology, University of Gdansk, Gdansk, Poland.
J Clin Exp Neuropsychol. 2010 Oct;32(8):881-9. doi: 10.1080/13803391003596454. Epub 2010 May 25.
Although individuals with end-stage renal disease (ESRD) who receive maintenance dialysis often present with memory deficits, the nature of this impairment remains controversial. Thus, this study was aimed to better characterize memory functioning of dialyzed patients and to identify potential predictors of their memory performance. A total of 61 dialyzed patients with ESRD and 30 demographically matched normal controls (NC) were the participants for this study. Overall, individuals with ESRD obtained significantly lower memory scores than NCs. Moreover, the pattern of their performance was consistent with that of subcortical cerebrovascular disease. Additionally, our results indicate that age, years of education and premorbid intelligence, depression symptoms, and blood urea nitrogen, as well as a history of coronary artery bypass grafting (CABG), are significant predictors of memory performance of adequately dialyzed patients with ESRD. Importantly, when the presence of CABG was controlled, the memory performance of dialyzed patients did not significantly differ from that of NCs.
虽然接受维持性透析的终末期肾病（ESRD）患者常伴有记忆缺陷，但这种损害的性质仍存在争议。因此，本研究旨在更好地描述透析患者的记忆功能，并确定其记忆表现的潜在预测因素。本研究共有 61 名 ESRD 透析患者和 30 名年龄、性别相匹配的正常对照组（NC）作为研究对象。总的来说，ESRD 患者的记忆评分明显低于 NC。此外，他们的表现模式与皮质下血管性痴呆一致。此外，我们的研究结果表明，年龄、受教育年限和术前智力、抑郁症状、血尿素氮以及冠状动脉旁路移植术（CABG）史是 ESRD 患者透析后记忆表现的显著预测因素。重要的是，当控制 CABG 的存在时，透析患者的记忆表现与 NC 没有显著差异。
