Division of Gastroenterology, Nakadori General Hospital, 3-15, Misono-cho, Minami-dori, Akita 010-8577, Japan.
World J Gastroenterol. 2010 May 28;16(20):2484-95. doi: 10.3748/wjg.v16.i20.2484.
To investigate whether semi-vegetarian diet (SVD) has a preventive effect against relapse of Crohn's disease (CD) in patients who have achieved remission, who are a high-risk group for relapse.
A prospective, single center, 2-year clinical trial was conducted. Twenty-two adult CD patients who achieved clinical remission either medically (n = 17) or surgically (n = 5) and consumed an SVD during hospitalization were advised to continue with an SVD and avoid known high-risk foods for inflammatory bowel disease. The primary endpoint was clinical relapse defined as the appearance of active symptoms of CD. Kaplan-Meier survival analysis was used to calculate the cumulative proportion of patients who had a relapse. A 2-year analysis of relapse rates of patients who followed an SVD and those who did not (an omnivorous diet group) was undertaken.
SVD was continued by 16 patients (compliance 73%). Remission was maintained in 15 of 16 patients (94%) in the SVD group vs two of six (33%) in the omnivorous group. Remission rate with SVD was 100% at 1 year and 92% at 2 years. SVD showed significant prevention in the time to relapse compared to that in the omnivorous group (P = 0.0003, log rank test). The concentration of C-reactive protein was normal at the final visit in more than half of the patients in remission who were taking an SVD, who maintained remission during the study (9/15; 60%), who terminated follow-up (8/12; 67%), and who completed 2 years follow-up (7/10; 70%). There was no untoward effect of SVD.
SVD was highly effective in preventing relapse in CD.
研究半素食饮食（SVD）是否对已缓解的克罗恩病（CD）患者（复发风险高的人群）的复发有预防作用。
进行了一项前瞻性、单中心、为期 2 年的临床试验。22 名成年 CD 患者在住院期间通过药物（n=17）或手术（n=5）实现临床缓解，并在住院期间食用 SVD，他们被建议继续食用 SVD 并避免已知的炎症性肠病高危食物。主要终点是临床复发，定义为出现 CD 的活跃症状。使用 Kaplan-Meier 生存分析计算复发患者的累积比例。对遵循 SVD 和未遵循 SVD（杂食饮食组）的患者进行了 2 年的复发率分析。
16 名患者（依从性 73%）继续食用 SVD。在 SVD 组中，16 名患者中有 15 名（94%）保持缓解，而在杂食组中只有 6 名中的 2 名（33%）保持缓解。SVD 组在 1 年时的缓解率为 100%，在 2 年时为 92%。SVD 在复发时间上明显优于杂食组（P=0.0003，对数秩检验）。在服用 SVD 的缓解患者中，超过一半的患者的 C 反应蛋白浓度在最后一次就诊时恢复正常，这些患者在研究期间保持缓解（9/15；60%），终止随访（8/12；67%），并完成 2 年随访（7/10；70%）。SVD 没有不良作用。
SVD 对预防 CD 复发非常有效。
