Mohran Zakaria Y, Abdel Kader Nadia A, Abdel Moez Amal T, Abbas Amal A
DepartmentS of Tropical Medicine, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt.
J Egypt Soc Parasitol. 2010 Apr;40(1):45-56.
The frequency of anti-thyroid antibodies and subclinical thyroid disorders in Egyptian patients with untreated chronic hepatitis type C was estimated. In addition, it determines the correlation between the seropositivity of anti-thyroid antibodies and serum thyroid stimulating hormone level in chronic HCV positive patients. Also, the impact of hepatic decompensation in inducing thyroid autoimmunity in such patients was evaluated. This study included 56 untreated chronic hepatitis C patients and 28 healthy subjects of the same local population as a control group. The results showed that the mean thyroid stimulating hormone levels were significantly higher in patients with chronic hepatitis C than in controls. Patients with decompensated chronic hepatitis C had insignificantly higher subsequent autoimmune hypothyroidism than the compensated patients. A significant positive correlation between the level of thyroid stimulating hormone and anti-thyroglobulin, but not with anti-thyroperoxidase, was found. Therefore, there is an association between chronic hepatitis C virus infection and subclinical autoimmune thyroid disorders. Thyroid stimulating hormone and anti-thyroglobulin antibodies screening for all chronic HCV patients, even if antiviral treatment will not be initiated, should be done.
评估了埃及未经治疗的丙型慢性肝炎患者中抗甲状腺抗体的频率和亚临床甲状腺疾病情况。此外，还确定了慢性丙型肝炎病毒阳性患者中抗甲状腺抗体血清阳性与血清促甲状腺激素水平之间的相关性。同时，评估了肝失代偿对这类患者诱发甲状腺自身免疫的影响。本研究纳入了56例未经治疗的丙型慢性肝炎患者以及28名来自同一当地人群的健康受试者作为对照组。结果显示，丙型慢性肝炎患者的平均促甲状腺激素水平显著高于对照组。失代偿性丙型慢性肝炎患者随后发生自身免疫性甲状腺功能减退的比例略高于代偿性患者。促甲状腺激素水平与抗甲状腺球蛋白之间存在显著正相关，但与抗甲状腺过氧化物酶无显著相关性。因此，丙型肝炎病毒感染与亚临床自身免疫性甲状腺疾病之间存在关联。即使不启动抗病毒治疗，也应对所有慢性丙型肝炎患者进行促甲状腺激素和抗甲状腺球蛋白抗体筛查。
