Saarela Jan, Finnäs Fjalar
Abo Akademi University, P.O. Box 311, 65101 Vasa, Finland.
Hum Biol. 2010 Feb;82(1):1-15. doi: 10.3378/027.082.0102.
Previous research has shown that the persistent regional mortality differences in Finland cannot be attributed to sociodemographic factors, health behaviors, or living conditions at young age. Using longitudinal population register data from Finland, we analyze the effect of birth region and ethnicity on mortality risks in men age 65-74 years and women age 75-84 years. Mortality from ischemic heart disease in particular is found to be highly influenced by these proxies for people's ancestry. The results are consistent with findings from population genetic and medical research, which says that genetic diversity is great across major regions of Finland and that this diversity may underlie variation in disease susceptibility. We argue that the regional mortality variation might reflect geographic clustering of hereditary factors, enforced by Finland's specific population development. We illustrate that large-scale population register data without genetic information or biomarkers can be useful for understanding cause-specific mortality within a national population.
先前的研究表明，芬兰持续存在的地区死亡率差异不能归因于社会人口因素、健康行为或年轻时的生活条件。利用来自芬兰的纵向人口登记数据，我们分析了出生地区和种族对65 - 74岁男性和75 - 84岁女性死亡风险的影响。特别是缺血性心脏病死亡率被发现受这些反映人们祖先的因素的高度影响。这些结果与群体遗传学和医学研究的发现一致，该研究表明芬兰主要地区的基因多样性很大，这种多样性可能是疾病易感性差异的基础。我们认为，地区死亡率差异可能反映了遗传因素的地理聚集，这是由芬兰特定的人口发展情况所强化的。我们表明，没有基因信息或生物标志物的大规模人口登记数据对于理解全国人口中特定病因的死亡率是有用的。
