Inserm, U844, Montpellier F-34091, France.
Stem Cell Res Ther. 2010 Mar 15;1(1):2. doi: 10.1186/scrt2.
Mesenchymal stem cells (MSCs) are multipotential nonhematopoietic progenitor cells that are isolated from many adult tissues, in particular from the bone marrow and adipose tissue. Along with their capacity for differentiating into cells of mesodermal lineage, such as adipocytes, osteoblasts and chondrocytes, these cells have also generated great interest for their ability to display immunomodulatory capacities. Indeed, a major breakthrough came with the finding that they are able to induce peripheral tolerance, suggesting they may be used as therapeutic tools in immune-mediated disorders. The present review aims at discussing the current knowledge on the targets and mechanisms of MSC-mediated immunosuppression as well as the potential use of MSCs as modulators of immune responses in a variety of diseases related to alloreactive immunity or autoimmunity.
间充质干细胞（MSCs）是多能非造血祖细胞，可从许多成人组织中分离出来，特别是从骨髓和脂肪组织中分离出来。这些细胞除了能够分化为中胚层谱系的细胞，如脂肪细胞、成骨细胞和成软骨细胞外，还因其具有免疫调节能力而引起了广泛关注。事实上，一个重大突破是发现它们能够诱导外周耐受，这表明它们可能被用作免疫介导性疾病的治疗工具。本综述旨在讨论 MSC 介导的免疫抑制的作用靶点和机制的最新知识，以及 MSCs 作为各种与同种异体免疫或自身免疫相关的疾病中免疫反应调节剂的潜在用途。
