Anisimov V N, Aleksandrov V A, Klimashevskiĭ V F, Kolodin V I, Likhachev A Ia
Vopr Onkol. 1978;24(1):64-70.
The authors report the data on the incidence of neoplasms in rats of the "Rappolovo" nursery breeding (USSR Acad. Med. Sci.) and their offsprings during 4 sequential generations kept in the vivarium of the N. N. Petrov Research Institute of Oncology of the USSR Ministry of Health. The frequency of spontaneous tumors in 213 male and 230 female rats was 25.8 and 35.7% accordingly. Totally, male animals developed 65 tumors, females--114. over 80% of all neoplasms developed in animals older than 18 months. The frequency of neoplasms of separate localizations in males and females was as follows: the hypophysis--7.0 and 12.6% correspondingly; the mammary gland--0.5 and 11.7%, the thyroid (thyroidal epithelium) - 1.4 and 3.0% and (light cells) 5.6 and 8.3%; the adrenal cortex--0.5 and 1.3%; the hematopoietic system --7.0 and 5.6%; parasitic sarcomas of the abdominal cavity --5.6 and 3.0%; the skin --0.4 and 0.4%; soft tissues --0.9 and 0%; the liver--0.4 and 0.4%; the kidneys --0.4 and 0.4%. Moreover, one male showed seminal vesicle tumor, and females-solitary neoplasms of the pancreas and salivary gland, the dura mater, the ovary and uterus. Significant differences were revealed in the frequency of spontaneous neoplasms in separate rat generations.
作者报告了“拉波洛沃”种鼠场（苏联医学科学院）的大鼠及其后代在苏联卫生部N.N.彼得罗夫肿瘤研究所实验动物饲养室内连续4代饲养期间的肿瘤发生率数据。213只雄性大鼠和230只雌性大鼠的自发肿瘤发生率分别为25.8%和35.7%。雄性动物共发生65例肿瘤，雌性动物发生114例。超过80%的肿瘤发生在18个月以上的动物中。雄性和雌性大鼠不同部位肿瘤的发生率如下：垂体分别为7.0%和12.6%；乳腺分别为0.5%和11.7%；甲状腺（甲状腺上皮）分别为1.4%和3.0%，（亮细胞）分别为5.6%和8.3%；肾上腺皮质分别为0.5%和1.3%；造血系统分别为7.0%和5.6%；腹腔寄生性肉瘤分别为5.6%和3.0%；皮肤分别为0.4%和0.4%；软组织分别为0.9%和0%；肝脏分别为0.4%和0.4%；肾脏分别为0.4%和0.4%。此外，一只雄性大鼠出现精囊肿瘤，雌性大鼠出现胰腺、唾液腺、硬脑膜、卵巢和子宫的孤立性肿瘤。不同代大鼠的自发肿瘤发生率存在显著差异。
