Center for Integrated Immunology and Vaccine Research, Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-1319, USA.
Int Immunol. 2010 Aug;22(8):619-25. doi: 10.1093/intimm/dxq053. Epub 2010 May 26.
Understanding the regulation of the CD8(+) T-cell response and how protective memory cells are generated has been intensely studied. It is now appreciated that a naive CD8(+) T cell requires at least three signals to mount an effective immune response: (i) TCR triggering, (ii) co-stimulation and (iii) inflammatory cytokines. Only recently have we begun to understand the molecular integration of those signals and how early events regulate the fate decisions of the responding CD8(+) T cells. This review will discuss the recent findings about both the extracellular and intracellular factors that regulate the destiny of responding CD8(+) T cells.
人们对 CD8(+) T 细胞反应的调控以及保护性记忆细胞的产生机制进行了深入研究。现在人们已经认识到，初始 CD8(+) T 细胞至少需要三个信号来产生有效的免疫反应：（i）TCR 触发，（ii）共刺激和（iii）炎性细胞因子。直到最近，我们才开始了解这些信号的分子整合以及早期事件如何调节应答 CD8(+) T 细胞的命运决定。本文将讨论有关调节应答 CD8(+) T 细胞命运的细胞外和细胞内因素的最新发现。
