Centre for Lung Infection, Papworth Hospital NHS Foundation Trust, Papworth Everard, Cambridge, United Kingdom.
Curr Opin Immunol. 2013 Jun;25(3):321-8. doi: 10.1016/j.coi.2013.05.010. Epub 2013 Jun 6.
Immunity to intracellular pathogens and cancer relies on the generation of robust CD8(+) T cell effector responses as well as the establishment of immunological memory. During a primary immune response CD8(+) T cells experience diverse extracellular environmental cues and cell-cell interactions that trigger downstream transcriptional programs ultimately guiding a CD8(+) T cell to undertake either an effector or a memory cell fate. Here, we discuss our current understanding of the signaling pathways and transcriptional networks that regulate effector and memory commitment in CD8(+) T lymphocytes.
细胞内病原体和癌症的免疫依赖于产生强大的 CD8(+) T 细胞效应应答以及建立免疫记忆。在初次免疫应答中，CD8(+) T 细胞经历各种细胞外环境线索和细胞间相互作用，触发下游转录程序，最终指导 CD8(+) T 细胞承担效应器或记忆细胞命运。在这里，我们讨论了我们对调节 CD8(+) T 淋巴细胞效应器和记忆细胞承诺的信号通路和转录网络的现有理解。
