精氨酸胰岛素与地特胰岛素混合使用不会影响 1 型糖尿病患儿的血糖波动。

Mixing insulin aspart with detemir does not affect glucose excursion in children with type 1 diabetes.

机构信息

Department of Pediatrics-Endocrinology Section, Nemours Children's Clinic, Jacksonville, Florida, USA.

出版信息

Diabetes Care. 2010 Aug;33(8):1750-2. doi: 10.2337/dc10-0169. Epub 2010 May 26.

DOI:10.2337/dc10-0169

PMID:20504899

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2909056/

Abstract

OBJECTIVE

We hypothesized that insulin detemir mixed with aspart had equivalent effects on blood glucose as if being given as separate injections in pediatric type 1 diabetes patients.

RESEARCH DESIGN AND METHODS

Fourteen children with type 1 diabetes were randomly assigned to either Study A (mixed insulins) or Study B (separate insulins) for the first 10 days and crossed over for the last 10 days. Each subject underwent continuous glucose monitoring on the last 72 h of each study.

RESULTS

The 48-h area under the curve (mmol/hour/l), M-value, and mean amplitude of glucose excursion (mmol/l) for Study A versus Study B were 457 +/- 70 versus 469 +/- 112 (P = 0.58), 39.67 +/- 15.37 versus 39.75 +/- 9.69 (P = 0.98), and 6.35 +/- 1.92 versus 5.98 +/- 0.92 (P = 0.42), respectively.

CONCLUSIONS

Insulin detemir mixed with aspart had equivalent effects on blood glucose versus giving them as separate injections in children with type 1 diabetes.

摘要

目的

我们假设在儿童 1 型糖尿病患者中，将地特胰岛素与门冬胰岛素混合使用的降血糖效果与分别注射两种胰岛素的效果相当。

研究设计与方法

14 例 1 型糖尿病患儿随机分为研究 A（混合胰岛素）组或研究 B（分别注射胰岛素）组，先分别接受 10 天的治疗，然后交叉接受另外 10 天的治疗。每个患儿在每个研究的最后 72 小时接受连续血糖监测。

结果

研究 A 与研究 B 的 48 小时血糖曲线下面积（mmol/hour/l）、M 值和血糖波动幅度（mmol/l）分别为 457±70 与 469±112（P=0.58）、39.67±15.37 与 39.75±9.69（P=0.98）和 6.35±1.92 与 5.98±0.92（P=0.42）。