Cengiz Eda
Division of Pediatric Endocrinology and Diabetes, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
J Diabetes Sci Technol. 2012 Jul 1;6(4):797-801. doi: 10.1177/193229681200600409.
Insulin therapy in youth with type 1 diabetes mellitus (T1DM) poses a special challenge because childhood is an unsteady state with increasing weight, height, and caloric needs, leading to varying insulin requirements. The current rapid-acting insulin analogs are not as fast and short-acting as needed to meet these challenges. This review describes the unique characteristics of insulin action in youth with T1DM based on previously published euglycemic clamp studies. It also explains the rationale behind the need for ultrafast-acting insulins to advance open- and closed-loop insulin therapy for the pediatric population with diabetes. Lastly, it briefly summarizes ongoing and future projects to accelerate insulin action in youth with T1DM.
在患有1型糖尿病（T1DM）的青少年中进行胰岛素治疗面临着特殊挑战，因为儿童期是一个体重、身高和热量需求不断增加的不稳定阶段，这导致胰岛素需求量不断变化。目前的速效胰岛素类似物在满足这些挑战所需的快速起效和短效方面还不够理想。本综述基于此前发表的正常血糖钳夹研究，描述了患有T1DM的青少年胰岛素作用的独特特征。它还解释了为何需要超速效胰岛素来推进针对糖尿病儿童群体的开环和闭环胰岛素治疗的基本原理。最后，它简要总结了正在进行的以及未来旨在加速T1DM青少年胰岛素作用的项目。
