Department of Embryology, Carnegie Institution for Science, Baltimore, Maryland 21218, USA.
Cold Spring Harb Perspect Biol. 2010 Jul;2(7):a000653. doi: 10.1101/cshperspect.a000653. Epub 2010 May 26.
The Cajal body (CB) is a nuclear organelle present in all eukaryotes that have been carefully studied. It is identified by the signature protein coilin and by CB-specific RNAs (scaRNAs). CBs contain high concentrations of splicing small nuclear ribonucleoproteins (snRNPs) and other RNA processing factors, suggesting that they are sites for assembly and/or posttranscriptional modification of the splicing machinery of the nucleus. The histone locus body (HLB) contains factors required for processing histone pre-mRNAs. As its name implies, the HLB is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action. CBs and HLBs are present throughout the interphase of the cell cycle, but disappear during mitosis. The biogenesis of CBs shows the features of a self-organizing structure.
Cajal 体（CB）是一种存在于所有已被深入研究的真核生物中的核细胞器。它由标志性蛋白 coilin 和 CB 特异性 RNA（scaRNAs）来识别。CB 中含有高浓度的剪接小核核糖核蛋白（snRNPs）和其他 RNA 加工因子，表明它们是核剪接机制组装和/或转录后修饰的场所。组蛋白基因座体（HLB）包含加工组蛋白前体 mRNA 所需的因子。顾名思义，HLB 与编码组蛋白的基因相关，表明它可能有助于将加工因子集中在其作用部位。CB 和 HLB 在细胞周期的整个间期都存在，但在有丝分裂期间消失。CB 的生物发生显示出自组织结构的特征。
