Liu Ying, Li Yin, Zhang Peipei
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
Key Laboratory for Neuroscience, Ministry of Education/National Health and Family Planning Commission, Peking University, Beijing 100083, China.
Protein Cell. 2025 Jun 20;16(6):418-438. doi: 10.1093/procel/pwae057.
Membrane-bound organelles and membraneless organelles (MLOs) coordinate various biological processes within eukaryotic cells. Among these, stress granules (SGs) are significant cytoplasmic MLOs that form in response to cellular stress, exhibiting liquid-like properties alongside stable substructures. SGs interact with diverse organelles, thereby influencing cellular pathways that are critical in both health and disease contexts. This review discusses the interplay between SGs and organelles and explores the methodologies employed to analyze interactions between SGs and other MLOs. Furthermore, it highlights the pivotal roles SGs play in regulating cellular responses and the pathogenesis of amyotrophic lateral sclerosis. Gaining insights into these interactions is essential for deciphering the mechanisms underlying both physiological processes and pathological conditions.
膜结合细胞器和无膜细胞器（MLOs）协调真核细胞内的各种生物过程。其中，应激颗粒（SGs）是重要的细胞质无膜细胞器，在细胞应激时形成，具有类似液体的特性以及稳定的亚结构。SGs与多种细胞器相互作用，从而影响在健康和疾病背景下都至关重要的细胞途径。本综述讨论了SGs与细胞器之间的相互作用，并探讨了用于分析SGs与其他MLOs之间相互作用的方法。此外，它强调了SGs在调节细胞反应和肌萎缩侧索硬化症发病机制中所起的关键作用。深入了解这些相互作用对于解读生理过程和病理状况背后的机制至关重要。
