Jonveaux P, Le Coniat M, Derré J, Vecchione D, Berger R
Unité INSERM U 301, Institut de Génétique Moléculaire, Paris, France.
Hematol Pathol. 1991;5(1):21-6.
Abnormalities of the short arm of chromosome 12 have been detected in a wide variety of hematopoietic disorders. Seven cases of non-Hodgkin's lymphoma (NHL) are reported with various rearrangements involving bands 12p13 or 12p11, associated with other chromosome changes. A review of the literature confirms that rearrangements of 12p, mainly at band 12p13, are nonrandom chromosomal abnormalities in all subtypes of NHL, as in other malignant blood disorders. No common translocation could, however, be detected, and 12p abnormalities may be considered as secondary chromosomal events. Most of the 12p rearrangements involving translocation of genetic material of unknown origin, suggest that they result in loss of 12p segment.
在多种造血系统疾病中均检测到了12号染色体短臂异常。本文报告了7例非霍奇金淋巴瘤（NHL），这些病例存在涉及12p13或12p11带的各种重排，并伴有其他染色体改变。文献综述证实，与其他恶性血液疾病一样，12p重排（主要在12p13带）是NHL所有亚型中的非随机染色体异常。然而，未检测到常见的易位，12p异常可能被视为继发性染色体事件。大多数涉及未知来源遗传物质易位的12p重排表明，它们会导致12p片段缺失。
