Department of Periodontology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
J Clin Periodontol. 2010 Jun;37(6):518-25. doi: 10.1111/j.1600-051X.2010.01562.x.
To test recolonization of periodontal lesions after full-mouth scaling and root planing (FM-SRP) or multiple session-SRP (MS-SRP) in a randomized clinical trial and whether FM-SRP and MS-SRP result in different clinical outcomes.
Thirty-nine subjects were randomly assigned to FM-SRP or MS-SRP groups. At baseline and after 3 months, probing pocket depth (PPD), plaque index (PlI) and bleeding on probing (BoP) were recorded. At baseline, immediately after treatment, after 1, 2, 7, 14 and 90 days, paper point samples from a single site from the maxillary right quadrant were collected for microbiological analysis of five putative pathogens by polymerase chain reaction.
FM-SRP and MS-SRP resulted in significant reductions in PPD, BoP and PlI and the overall detection frequencies of the five species after 3 months without significant differences between treatments. Compared with MS-SRP, FM-SRP resulted in less recolonization of the five species, significantly for Treponema denticola, in the tested sites.
FM-SRP and MS-SRP result in overall clinically and microbiologically comparable outcomes where recolonization of periodontal lesions may be better prevented by FM-SRP.
在一项随机临床试验中测试全口洁治和根面平整（FM-SRP）或多次洁治和根面平整（MS-SRP）后牙周病损的再定植情况，并比较 FM-SRP 和 MS-SRP 是否会产生不同的临床效果。
39 名受试者被随机分配到 FM-SRP 或 MS-SRP 组。在基线和 3 个月时，记录探诊袋深度（PPD）、菌斑指数（PlI）和探诊出血（BoP）。在基线、治疗后即刻、治疗后 1、2、7、14 和 90 天，从右上象限的单个位点采集纸尖样本，通过聚合酶链反应（PCR）对五种假定病原体进行微生物分析。
FM-SRP 和 MS-SRP 在 3 个月后均显著降低了 PPD、BoP 和 PlI，且五种菌的总检出频率在治疗之间无显著差异。与 MS-SRP 相比，FM-SRP 使测试位点的五种菌（尤其是牙龈卟啉单胞菌）再定植的情况明显减少。
FM-SRP 和 MS-SRP 在总体上具有相似的临床和微生物学效果，但 FM-SRP 可能更能预防牙周病损的再定植。
