• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

贝尔法斯特 90 岁以上老人：是先天还是后天？免疫、心血管和遗传因素。

BELFAST nonagenarians: nature or nurture? Immunological, cardiovascular and genetic factors.

机构信息

Department of Geriatric Medicine, School of Medicine, Dentistry and Biomedical Science, Queens University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland.

出版信息

Immun Ageing. 2010 May 27;7:6. doi: 10.1186/1742-4933-7-6.

DOI:10.1186/1742-4933-7-6
PMID:20507630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2902418/
Abstract

Nonagenarians are the fastest growing sector of populations across Western European and the developed world. They are some of the oldest members of our societies and survivors of their generation and may help us understand how to age not only longer, but better.The Belfast Longevity Group enlisted the help of 500 community-living, mobile, mentally competent, 'elite' nonagenarians, as part of an ongoing study of ageing. We assessed some immunological, cardiovascular, nutritional and genetic factors and some aspects of their interaction in this group of 'oldest old'.Here we present some of the evidence related to genetic and nutritional factors which seem to be important for good quality ageing in nonagenarians from the Belfast Elderly Longitudinal Free-living Ageing STudy (BELFAST).

摘要

在西欧和发达世界，90 岁以上的老年人是人口增长最快的群体。他们是社会中最年长的成员之一，也是他们那一代人的幸存者，他们的存在可能有助于我们理解如何不仅活得更长，而且活得更好。作为一项正在进行的衰老研究的一部分，贝尔法斯特长寿小组招募了 500 名生活在社区、行动自如、精神健全的“精英”90 岁以上的老年人。我们评估了这组“最年长的老年人”的一些免疫、心血管、营养和遗传因素，以及它们之间的一些相互作用。在这里，我们介绍了一些与遗传和营养因素有关的证据，这些因素似乎对来自贝尔法斯特老年人纵向自由生活衰老研究（BELFAST）的 90 岁以上老年人的高质量衰老很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ff/2902418/389834437489/1742-4933-7-6-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ff/2902418/2530b48f1810/1742-4933-7-6-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ff/2902418/db8786dbc0c4/1742-4933-7-6-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ff/2902418/1a5fde74f69b/1742-4933-7-6-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ff/2902418/389834437489/1742-4933-7-6-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ff/2902418/2530b48f1810/1742-4933-7-6-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ff/2902418/db8786dbc0c4/1742-4933-7-6-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ff/2902418/1a5fde74f69b/1742-4933-7-6-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ff/2902418/389834437489/1742-4933-7-6-4.jpg

相似文献

1
BELFAST nonagenarians: nature or nurture? Immunological, cardiovascular and genetic factors.贝尔法斯特 90 岁以上老人：是先天还是后天？免疫、心血管和遗传因素。
Immun Ageing. 2010 May 27;7:6. doi: 10.1186/1742-4933-7-6.
2
Genes and life-style factors in BELFAST nonagenarians: Nature, Nurture and Narrative.贝尔法斯特九旬老人的基因与生活方式因素：天性、教养与人生故事
Biogerontology. 2015 Oct;16(5):587-97. doi: 10.1007/s10522-015-9567-y. Epub 2015 Mar 14.
3
Mitochondrial J haplogroup is associated with lower blood pressure and anti-oxidant status: findings in octo/nonagenarians from the BELFAST Study.线粒体J单倍群与较低的血压和抗氧化状态相关：来自贝尔法斯特研究的八旬/九旬老人的研究结果。
Age (Dordr). 2013 Aug;35(4):1445-56. doi: 10.1007/s11357-012-9444-4. Epub 2012 Jul 10.
4
BELFAST centenarians: a case of optimised cardiovascular risk?贝尔法斯特百岁老人：心血管风险优化病例？
Curr Pharm Des. 2010;16(7):789-95. doi: 10.2174/138161210790883697.
5
Malondialdehyde and measures of antioxidant activity in subjects from the Belfast Elderly Longitudinal Free-living Aging Study.来自贝尔法斯特老年人纵向自由生活衰老研究的受试者体内的丙二醛及抗氧化活性指标
Ann N Y Acad Sci. 2004 Jun;1019:392-5. doi: 10.1196/annals.1297.070.
6
Insights Into Sibling Relationships and Longevity From Genetics of Healthy Ageing Nonagenarians: The Importance of Optimisation, Resilience and Social Networks.从健康衰老的九旬老人遗传学看兄弟姐妹关系与长寿：优化、适应力和社交网络的重要性
Front Psychol. 2022 May 6;13:722286. doi: 10.3389/fpsyg.2022.722286. eCollection 2022.
7
Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity.意大利南部九旬老人的心血管健康：一项基于家庭的长寿横断面试点研究。
J Cardiovasc Med (Hagerstown). 2020 Feb;21(2):89-98. doi: 10.2459/JCM.0000000000000910.
8
Nature or nurture; BMI and blood pressure at 90. Findings from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST).先天还是后天；90岁时的体重指数和血压。贝尔法斯特老年人纵向自由生活衰老研究（BELFAST）的结果。
Age (Dordr). 2009 Dec;31(4):261-7. doi: 10.1007/s11357-009-9096-1.
9
Apolipoprotein E alleles in nonagenarian subjects in the Belfast Elderly Longitudinal Free-living Ageing Study (BELFAST).贝尔法斯特老年人纵向自由生活衰老研究（BELFAST）中百岁老人的载脂蛋白E等位基因。
Mech Ageing Dev. 2001 Sep 15;122(13):1367-72. doi: 10.1016/s0047-6374(01)00278-0.
10
Gender effect on well-being of the oldest old: a survey of nonagenarians living in Tuscany: the Mugello study.性别对最年长老年人幸福感的影响：居住在托斯卡纳的 90 岁以上老年人的调查：穆杰罗研究。
Neurol Sci. 2018 Mar;39(3):509-517. doi: 10.1007/s10072-017-3223-z. Epub 2018 Jan 8.

引用本文的文献

1
Characteristics, outcomes, and complications among nonagenarian and centenarian patients admitted to the intensive care unit: a scoping review.入住重症监护病房的九旬和百岁患者的特征、结局及并发症：一项范围综述
Crit Care. 2025 Mar 13;29(1):112. doi: 10.1186/s13054-025-05349-z.
2
Why does age at HIV infection correlate with set point viral load? An evolutionary hypothesis.为什么感染 HIV 的年龄与病毒载量有关？一种进化假说。
Epidemics. 2022 Dec;41:100629. doi: 10.1016/j.epidem.2022.100629. Epub 2022 Sep 21.
3
Triple jeopardy in ageing: COVID-19, co-morbidities and inflamm-ageing.

本文引用的文献

1
Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil.代谢综合征患者急性摄入富含酚的初榨橄榄油后单核细胞基因表达的变化。
BMC Genomics. 2010 Apr 20;11:253. doi: 10.1186/1471-2164-11-253.
2
Association between APOE epsilon4 allele and vascular dementia: The Cache County study.载脂蛋白 E ɛ4 等位基因与血管性痴呆的关系：Cache 县研究。
Dement Geriatr Cogn Disord. 2010;29(3):248-53. doi: 10.1159/000285166. Epub 2010 Apr 6.
3
The effect of ageing on human lymphocyte subsets: comparison of males and females.
衰老三重困境：COVID-19、合并症和炎症衰老。
Ageing Res Rev. 2022 Jan;73:101494. doi: 10.1016/j.arr.2021.101494. Epub 2021 Oct 22.
4
Health profiles and socioeconomic characteristics of nonagenarians residing in Mugello, a rural area in Tuscany (Italy).居住在托斯卡纳（意大利）穆杰罗地区的 90 岁以上老人的健康状况和社会经济特征。
BMC Geriatr. 2020 Aug 15;20(1):289. doi: 10.1186/s12877-020-01689-3.
5
Immunosuppression and HIV Viremia Associated with More Atherogenic Lipid Profile in Older People with HIV.免疫抑制和HIV病毒血症与老年HIV感染者更易致动脉粥样硬化的血脂谱相关。
AIDS Res Hum Retroviruses. 2019 Jan;35(1):81-91. doi: 10.1089/AID.2018.0145. Epub 2018 Nov 27.
6
Does aging affect the immune status? A comparative analysis in 300 healthy volunteers from France, Austria and Spain.衰老是如何影响免疫状态的？来自法国、奥地利和西班牙的 300 名健康志愿者的对比分析。
Immun Ageing. 2013 Sep 6;10(1):38. doi: 10.1186/1742-4933-10-38.
7
Killer Immunoglobulin-like Receptors (KIR) haplogroups A and B track with Natural Killer Cells and Cytokine Profile in Aged Subjects: Observations from Octo/Nonagenarians in the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST).杀伤细胞免疫球蛋白样受体 (KIR) 单倍型 A 和 B 与老年受试者的自然杀伤细胞和细胞因子谱相关：来自贝尔法斯特老年人纵向自由生活老龄化研究 (BELFAST) 的八十/九十多岁人群的观察结果。
Immun Ageing. 2013 Aug 19;10(1):35. doi: 10.1186/1742-4933-10-35.
8
Ageing and long-term CD4 cell count trends in HIV-positive patients with 5 years or more combination antiretroviral therapy experience.具有 5 年以上联合抗逆转录病毒治疗经验的 HIV 阳性患者的衰老和长期 CD4 细胞计数趋势。
HIV Med. 2013 Apr;14(4):208-16. doi: 10.1111/j.1468-1293.2012.01053.x. Epub 2012 Oct 4.
9
Mitochondrial J haplogroup is associated with lower blood pressure and anti-oxidant status: findings in octo/nonagenarians from the BELFAST Study.线粒体J单倍群与较低的血压和抗氧化状态相关：来自贝尔法斯特研究的八旬/九旬老人的研究结果。
Age (Dordr). 2013 Aug;35(4):1445-56. doi: 10.1007/s11357-012-9444-4. Epub 2012 Jul 10.
年龄对人类淋巴细胞亚群的影响：男性与女性的比较。
Immun Ageing. 2010 Mar 16;7:4. doi: 10.1186/1742-4933-7-4.
4
Study of lymphocyte subpopulations in bone marrow in a model of protein-energy malnutrition.蛋白质-能量营养不良模型中骨髓淋巴细胞亚群的研究。
Nutrition. 2010 Oct;26(10):1021-8. doi: 10.1016/j.nut.2009.08.026. Epub 2009 Dec 29.
5
Differential effect of IL-1β and TNFα on the production of IL-6, IL-8 and PGE2 in fibroblast-like synoviocytes and THP-1 macrophages.白细胞介素-1β和肿瘤坏死因子-α对成纤维样滑膜细胞和 THP-1 巨噬细胞产生白细胞介素-6、白细胞介素-8 和前列腺素 E2 的差异影响。
Rheumatol Int. 2010 Jun;30(8):1025-33. doi: 10.1007/s00296-009-1089-y. Epub 2009 Aug 21.
6
Comparison of cytokine expression in mesenchymal stem cells from human placenta, cord blood, and bone marrow.人胎盘、脐带血和骨髓间充质干细胞中细胞因子表达的比较。
J Korean Med Sci. 2009 Aug;24(4):547-54. doi: 10.3346/jkms.2009.24.4.547. Epub 2009 Jul 29.
7
Transgenerational epigenetic inheritance: prevalence, mechanisms, and implications for the study of heredity and evolution.跨代表观遗传继承：普遍性、机制及其对遗传与进化研究的意义
Q Rev Biol. 2009 Jun;84(2):131-76. doi: 10.1086/598822.
8
Human innate immunosenescence: causes and consequences for immunity in old age.人类先天性免疫衰老：老年免疫的原因及后果
Trends Immunol. 2009 Jul;30(7):325-33. doi: 10.1016/j.it.2009.05.004. Epub 2009 Jun 21.
9
Nature or nurture; BMI and blood pressure at 90. Findings from the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST).先天还是后天；90岁时的体重指数和血压。贝尔法斯特老年人纵向自由生活衰老研究（BELFAST）的结果。
Age (Dordr). 2009 Dec;31(4):261-7. doi: 10.1007/s11357-009-9096-1.
10
Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss.肥胖与心血管疾病：风险因素、矛盾之处及体重减轻的影响。
J Am Coll Cardiol. 2009 May 26;53(21):1925-32. doi: 10.1016/j.jacc.2008.12.068.