Texas Scottish Rite Hospital for Children, Dallas, TX.
Spine (Phila Pa 1976). 2018 Jan 15;43(2):133-140. doi: 10.1097/BRS.0b013e3181c80ec5.
Morphometic analysis of the thoracic and lumbar pedicle, vertebral body, and spinal canal in the normal infantile and juvenile patients using magnetic resonance imaging (MRI).
To 3-dimensionally characterize the growth of the vertebral column in vivo and define the accurate dynamic growth rate of the normal immature spine.
There is a relationship between growth of the spine and the development of spinal deformity. Currently available information regarding vertebral column growth is remarkably limited and poorly defined. The detailed morphologic research is needed to obtain accurate data with regard to growth of the vertebra, including coronal, sagittal, and axial growth information for normal states.
A total of 34 pediatric patients with a normal straight spine who had MRI from thoracic vertebra 1 to lumbar vertebra 5 were assigned to 3 groups: infantile group (n = 11), 0 to 3 years of age; juvenile-young group (n = 16), 4 to 7 years of age; and juvenile-old group (n = 7), 8 to 10 years of age. True transverse and midsagittal MRI images were used for pedicle (width and length), vertebral body (height, depth and width), and spinal canal area measurements.
The mean increase of the pedicle width and length was 0.7 mm (16%) and 3.2 mm (18%) from the infantile to the juvenile-young, and was 0.9 mm (15%) and 2.2 mm (11%) through the juvenile-old group. The mean increase of the vertebra body width, depth, and height were 3.6 mm (15%), 4.5 mm (27%), and 3.1 mm (27%), respectively, from the infantile to the juvenile-young, and were 2.9 mm (10%), 1.9 mm (9%) and 2.1 mm (15%), respectively, through the juvenile-old group. The mean increase of the spinal canal area was 41 mm (19%) from the infantile to the juvenile-young and was only 1.8 mm (0.7%) through the juvenile-old group.
The current study established the growth of the pedicle, spinal canal, and vertebral body in vivo in a sample of normal pediatric subjects. The vertebral growth rate in the infantile and the juvenile-young period was significantly greater than that in the juvenile-old period. Spinal canal growth is associated with the growth of the pedicle width and has little growth after the juvenile-young period. Pedicle screw fixation would be unlikely to influence the size of the spinal canal after the early juvenile period, but may disturb the pedicle growth in length.
使用磁共振成像（MRI）对正常婴儿和青少年患者的胸腰椎椎弓根、椎体和椎管进行形态计量学分析。
三维描述脊柱的生长，并确定正常未成熟脊柱的准确动态生长率。
脊柱生长与脊柱畸形的发展有关。目前有关脊柱生长的信息非常有限，定义也很差。需要进行详细的形态学研究，以获得有关椎体生长的准确数据，包括正常状态下冠状、矢状和轴向生长信息。
共纳入 34 例胸椎 1 至腰椎 5 行 MRI 检查的正常直脊柱儿童患者，分为 3 组：婴儿组（n=11），0 至 3 岁；青少年-年轻组（n=16），4 至 7 岁；青少年-年长组（n=7），8 至 10 岁。使用真实的横断位和正中矢状面 MRI 图像进行椎弓根（宽度和长度）、椎体（高度、深度和宽度）和椎管面积测量。
从婴儿期到青少年-年轻期，椎弓根宽度和长度的平均增加量分别为 0.7mm（16%）和 3.2mm（18%），从青少年-年长组分别为 0.9mm（15%）和 2.2mm（11%）。椎体宽度、深度和高度的平均增加量分别为 3.6mm（15%）、4.5mm（27%）和 3.1mm（27%），从婴儿期到青少年-年轻期，从青少年-年长组分别为 2.9mm（10%）、1.9mm（9%）和 2.1mm（15%）。椎管面积的平均增加量为 41mm（19%），从婴儿期到青少年-年轻期，仅为 1.8mm（0.7%），通过青少年-年长组。
本研究在正常儿科患者样本中建立了椎弓根、椎管和椎体的体内生长。婴儿期和青少年-年轻期的椎体生长速度明显大于青少年-年长期。椎管生长与椎弓根宽度的生长有关，青少年-年轻期后生长较少。在早期青少年期后，椎弓根螺钉固定不太可能影响椎管的大小，但可能会干扰椎弓根的长度生长。
