Abu Fanas S H, Drucker D B, Hull P S
Department of Restorative Dentistry, Turner Dental School, University of Manchester, UK.
J Dent. 1991 Apr;19(2):97-9. doi: 10.1016/0300-5712(91)90098-j.
The effects of tetracycline and amoxycillin with clavulanic acid on the clinical parameters and subgingival flora of eight patients with rapidly progressive periodontitis was assessed. Subjects received either tetracycline 250 mg four times daily or amoxycillin 250 mg with clavulanic acid 125 mg three times daily for a period of 2 weeks together with subgingival scaling and root planning. Both treatment regimens produced significant reductions in bleeding on probing and probing pocket depths which were still present 16 weeks after the antibiotic therapy. A significant reduction in the mean percentage of black-pigmented Bacteroides spp., Fusobacterium nucleatum and anaerobic corroding bacilli was also obtained. Both treatment regimens were equally effective in reducing the clinical parameter and altering the subgingival flora. The MIC values for Bacteroides gingivalis (Porphyromonas gingivalis). Bacteroides intermedius (Prevotella intermedia) and F. nucleatum to amoxycillin with clavulanic acid remained constant throughout the period of investigation. The MIC values of these organisms to tetracycline increased.
评估了四环素以及阿莫西林与克拉维酸联用对8例快速进展性牙周炎患者临床指标和龈下菌群的影响。受试者接受每日4次、每次250mg的四环素治疗，或每日3次、每次250mg阿莫西林与125mg克拉维酸的联合治疗，为期2周，同时进行龈下刮治和根面平整。两种治疗方案均使探诊出血和探诊袋深度显著降低，在抗生素治疗后16周时这些指标仍保持降低。黑色普氏菌属、具核梭杆菌和厌氧腐蚀杆菌的平均百分比也显著降低。两种治疗方案在降低临床指标和改变龈下菌群方面同样有效。牙龈卟啉单胞菌、中间普氏菌和具核梭杆菌对阿莫西林与克拉维酸的最低抑菌浓度值在整个研究期间保持不变。这些微生物对四环素的最低抑菌浓度值升高。
