Division of Rheumatology, University of Colorado School of Medicine, 1775 Aurora Court, Mail Stop B-115, Aurora, CO 80045, USA.
Rheum Dis Clin North Am. 2010 May;36(2):213-41. doi: 10.1016/j.rdc.2010.02.001.
Rheumatoid arthritis (RA) likely develops in several phases, beginning with genetic risk, followed by asymptomatic autoimmunity, then finally, clinically apparent disease. Investigating the phases of disease that exist prior to the onset of symptoms (ie, the preclinical period of RA) will lead to understanding of the important relationships between genetic and environmental factors that may lead to disease, as well as allow for the development of predictive models for disease, and ultimately preventive strategies for RA.
类风湿关节炎（RA）可能经历几个阶段发展，首先是遗传风险，接着是无症状自身免疫，最后是临床表现明显的疾病。研究疾病在症状出现之前的阶段（即 RA 的临床前期）将有助于了解遗传和环境因素之间的重要关系，这些因素可能导致疾病，也为疾病预测模型的开发以及最终的 RA 预防策略提供依据。
