类风湿关节炎的临床前研究：鉴定、评估和未来研究方向。
Preclinical rheumatoid arthritis: identification, evaluation, and future directions for investigation.
机构信息
Division of Rheumatology, University of Colorado School of Medicine, 1775 Aurora Court, Mail Stop B-115, Aurora, CO 80045, USA.
出版信息
Rheum Dis Clin North Am. 2010 May;36(2):213-41. doi: 10.1016/j.rdc.2010.02.001.
Abstract
Rheumatoid arthritis (RA) likely develops in several phases, beginning with genetic risk, followed by asymptomatic autoimmunity, then finally, clinically apparent disease. Investigating the phases of disease that exist prior to the onset of symptoms (ie, the preclinical period of RA) will lead to understanding of the important relationships between genetic and environmental factors that may lead to disease, as well as allow for the development of predictive models for disease, and ultimately preventive strategies for RA.
摘要
类风湿关节炎（RA）可能经历几个阶段发展，首先是遗传风险，接着是无症状自身免疫，最后是临床表现明显的疾病。研究疾病在症状出现之前的阶段（即 RA 的临床前期）将有助于了解遗传和环境因素之间的重要关系，这些因素可能导致疾病，也为疾病预测模型的开发以及最终的 RA 预防策略提供依据。
相似文献
1
Preclinical rheumatoid arthritis: identification, evaluation, and future directions for investigation.类风湿关节炎的临床前研究：鉴定、评估和未来研究方向。
Rheum Dis Clin North Am. 2010 May;36(2):213-41. doi: 10.1016/j.rdc.2010.02.001.
2
Preclinical rheumatoid arthritis (autoantibodies): an updated review.临床前类风湿关节炎（自身抗体）：更新综述。
Curr Rheumatol Rep. 2014 May;16(5):419. doi: 10.1007/s11926-014-0419-6.
3
Preclinical rheumatoid arthritis and rheumatoid arthritis prevention.类风湿关节炎的临床前阶段和类风湿关节炎的预防。
Curr Opin Rheumatol. 2020 May;32(3):289-296. doi: 10.1097/BOR.0000000000000708.
4
Insights from populations at risk for the future development of classified rheumatoid arthritis.来自有患分类类风湿关节炎未来发展风险人群的见解。
Rheum Dis Clin North Am. 2014 Nov;40(4):605-20. doi: 10.1016/j.rdc.2014.07.003. Epub 2014 Sep 6.
5
Multiple cytokines and chemokines are associated with rheumatoid arthritis-related autoimmunity in first-degree relatives without rheumatoid arthritis: Studies of the Aetiology of Rheumatoid Arthritis (SERA).多种细胞因子和趋化因子与类风湿关节炎相关自身免疫相关，一级亲属中无类风湿关节炎：类风湿关节炎病因学研究（SERA）。
Ann Rheum Dis. 2013 Jun;72(6):901-7. doi: 10.1136/annrheumdis-2012-201505. Epub 2012 Aug 21.
6
Antibodies to citrullinated protein antigens (ACPAs): clinical and pathophysiologic significance.抗瓜氨酸化蛋白抗体（ACPAs）：临床和病理生理意义。
Curr Rheumatol Rep. 2011 Oct;13(5):421-30. doi: 10.1007/s11926-011-0193-7.
7
The role of ACPAs in at-risk individuals: Early targeting of the bone and joints.抗环瓜氨酸肽抗体在高危人群中的作用：早期针对骨骼和关节。
Best Pract Res Clin Rheumatol. 2017 Feb;31(1):53-58. doi: 10.1016/j.berh.2017.09.015. Epub 2017 Nov 6.
8
The Natural History of Rheumatoid Arthritis.类风湿关节炎的自然病史。
Clin Ther. 2019 Jul;41(7):1256-1269. doi: 10.1016/j.clinthera.2019.04.028. Epub 2019 Jun 10.
9
Predicting Rheumatoid Arthritis in At-risk Individuals.预测高危人群中的类风湿关节炎。
Clin Ther. 2019 Jul;41(7):1286-1298. doi: 10.1016/j.clinthera.2019.04.017. Epub 2019 Jun 10.
10
Familial clustering of the serum cytokine profile in the relatives of rheumatoid arthritis patients.类风湿关节炎患者亲属血清细胞因子谱的家族聚集性。
Arthritis Rheum. 2012 Jun;64(6):1720-9. doi: 10.1002/art.34449. Epub 2012 Feb 21.
引用本文的文献
1
Treating connective tissue disease-associated interstitial lung disease - think outside the box: a perspective.治疗结缔组织病相关间质性肺病——跳出框框思考：一种观点
Eur Respir Rev. 2025 Jul 23;34(177). doi: 10.1183/16000617.0046-2025. Print 2025 Jul.
2
Crystalline silica exposure induces multiple systemic autoimmune phenotypes including inflammatory arthritis and nephritis in Collaborative Cross mice with differing sub-clinical autoimmune profiles.在具有不同亚临床自身免疫特征的协作杂交小鼠中，接触结晶二氧化硅会诱发多种全身性自身免疫表型，包括炎性关节炎和肾炎。
bioRxiv. 2025 May 27:2025.05.22.655650. doi: 10.1101/2025.05.22.655650.
3
Trajectories of health status and their association with rheumatoid arthritis risk: insights from a national prospective cohort study.健康状况轨迹及其与类风湿关节炎风险的关联：一项全国前瞻性队列研究的见解
BMC Public Health. 2025 Mar 25;25(1):1132. doi: 10.1186/s12889-025-22303-4.
4
Rheumatoid Factor: Diagnostic and Prognostic Performance and Therapeutic Implications in Rheumatoid Arthritis.类风湿因子：类风湿关节炎的诊断、预后评估及治疗意义
J Clin Med. 2025 Feb 25;14(5):1529. doi: 10.3390/jcm14051529.
5
Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis.深度免疫表型分析揭示了类风湿关节炎高危个体中循环活化淋巴细胞的存在。
J Clin Invest. 2025 Mar 17;135(6):e185217. doi: 10.1172/JCI185217.
6
Role of TLR4 activation and signaling in bone remodeling, and afferent sprouting in serum transfer arthritis.Toll样受体4（TLR4）激活和信号传导在骨重塑以及血清转移型关节炎传入神经纤维芽生中的作用
Arthritis Res Ther. 2024 Dec 18;26(1):212. doi: 10.1186/s13075-024-03424-4.
7
Substitution of Glutamic Acid at Position 71 of DRβ1*04:01 and Collagen-Specific Tolerance Without Alloreactivity.DRβ1*04:01第71位谷氨酸的替代与无同种异体反应性的胶原特异性耐受性。
Arthritis Rheumatol. 2025 May;77(5):526-535. doi: 10.1002/art.43067. Epub 2025 Jan 21.
8
Maternal autoimmune disease and its association with childhood cancer: A population-based case-control study in Denmark.母体自身免疫性疾病及其与儿童癌症的关联：丹麦一项基于人群的病例对照研究。
EJC Paediatr Oncol. 2024 Jun;3. doi: 10.1016/j.ejcped.2024.100145. Epub 2024 Jan 19.
9
Autoimmune Disease-Related Dry Eye Diseases and Their Placement Under the Revised Classification Systems: An Update.自身免疫性疾病相关干眼疾病及其在修订分类系统中的定位：最新进展
Cureus. 2023 Dec 10;15(12):e50276. doi: 10.7759/cureus.50276. eCollection 2023 Dec.
10
Identification and Development of Synovial B-Cell-Related Genes Diagnostic Signature for Rheumatoid Arthritis.鉴定和开发与滑膜 B 细胞相关的基因诊断标志物用于类风湿关节炎。
J Immunol Res. 2023 Nov 25;2023:9422990. doi: 10.1155/2023/9422990. eCollection 2023.
本文引用的文献
1
A prospective approach to investigating the natural history of preclinical rheumatoid arthritis (RA) using first-degree relatives of probands with RA.一种利用类风湿关节炎（RA）先证者的一级亲属来研究临床前期类风湿关节炎自然史的前瞻性方法。
Arthritis Rheum. 2009 Dec 15;61(12):1735-42. doi: 10.1002/art.24833.
2
Identification of undiagnosed inflammatory arthritis in a community health fair screen.在社区健康博览筛查中识别未确诊的炎性关节炎。
Arthritis Rheum. 2009 Dec 15;61(12):1642-9. doi: 10.1002/art.24834.
3
Autoimmunity against fibrinogen mediates inflammatory arthritis in mice.纤维蛋白原自身免疫介导小鼠炎症性关节炎。
J Immunol. 2010 Jan 1;184(1):379-90. doi: 10.4049/jimmunol.0901639. Epub 2009 Nov 30.
4
Impact of T-cell costimulation modulation in patients with undifferentiated inflammatory arthritis or very early rheumatoid arthritis: a clinical and imaging study of abatacept (the ADJUST trial).T 细胞共刺激调节对未分化炎性关节炎或早期类风湿关节炎患者的影响：阿巴西普（ADJUST 试验）的临床和影像学研究。
Ann Rheum Dis. 2010 Mar;69(3):510-6. doi: 10.1136/ard.2009.119016. Epub 2009 Nov 23.
5
Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis.特定基因型、吸烟与瓜氨酸化α烯醇化酶自身免疫在类风湿关节炎发病机制中的特异性相互作用。
Nat Genet. 2009 Dec;41(12):1319-24. doi: 10.1038/ng.480. Epub 2009 Nov 8.
6
Immunotherapy for the prevention and treatment of type 1 diabetes: human trials and a look into the future.1型糖尿病预防与治疗的免疫疗法：人体试验及未来展望
Diabetes Care. 2009 Oct;32(10):1769-82. doi: 10.2337/dc09-0374.
7
Genetic susceptibility to rheumatoid arthritis: an emerging picture.类风湿关节炎的遗传易感性：一幅逐渐清晰的图景。
Arthritis Rheum. 2009 Oct 15;61(10):1441-6. doi: 10.1002/art.24672.
8
Rheumatoid arthritis genetics: 2009 update.类风湿关节炎遗传学：2009年更新
Curr Rheumatol Rep. 2009 Oct;11(5):351-6. doi: 10.1007/s11926-009-0050-0.
9
Exposure to traffic pollution and increased risk of rheumatoid arthritis.暴露于交通污染与类风湿关节炎风险增加
Environ Health Perspect. 2009 Jul;117(7):1065-9. doi: 10.1289/ehp.0800503. Epub 2009 Mar 4.
10
Periodontitis and rheumatoid arthritis: epidemiologic, clinical, and immunologic associations.牙周炎与类风湿性关节炎：流行病学、临床及免疫学关联
Compend Contin Educ Dent. 2009 May;30(4):188-90, 192, 194 passim; quiz 198, 210.
Zotero 插件