自身免疫性疾病相关干眼疾病及其在修订分类系统中的定位：最新进展
Autoimmune Disease-Related Dry Eye Diseases and Their Placement Under the Revised Classification Systems: An Update.
作者信息
Kılıççıoğlu Alara, Oncel Deniz, Celebi Ali Riza Cenk
机构信息
Neurology, Szeged University, Szeged, HUN.
Ophthalmology, Acibadem University, Istanbul, TUR.
出版信息
Cureus. 2023 Dec 10;15(12):e50276. doi: 10.7759/cureus.50276. eCollection 2023 Dec.
Abstract
Dry eye disease (DED) is a chronic and progressive disorder involving the ocular surface, characterized by disturbances in tear film composition, instability of the tear film, and inflammation of the ocular surface. There are two forms of DED: aqueous-deficient dry eye (ADDE) and evaporative dry eye (EDE). Autoimmune diseases are systemic disorders involving multiple organs, including the eyes, and have a significant impact on DED. There have been multiple studies demonstrating the relation between autoimmune diseases and DED. This article reviews the current knowledge regarding the epidemiological characteristics, pathogenesis, and treatments of autoimmune disease-related DED.
摘要
干眼症（DED）是一种累及眼表的慢性进行性疾病，其特征在于泪膜成分紊乱、泪膜不稳定以及眼表炎症。干眼症有两种类型：泪液分泌不足型干眼症（ADDE）和蒸发过强型干眼症（EDE）。自身免疫性疾病是累及包括眼睛在内的多个器官的全身性疾病，对干眼症有重大影响。已有多项研究证明自身免疫性疾病与干眼症之间的关系。本文综述了目前关于自身免疫性疾病相关性干眼症的流行病学特征、发病机制和治疗方法的知识。
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