Pediatric Infectious Diseases, University of Colorado Denver, Mail Stop C227, Building 401, 1784 Racine Street, Room R09-108, Aurora, CO 80045, USA.
J Clin Virol. 2010 May;48 Suppl 1(Suppl 1):S14-9. doi: 10.1016/S1386-6532(10)70004-4.
Impairment of varicella zoster virus (VZV)-specific cell-mediated immunity, including impairment due to immunosenescence, is associated with an increased risk of developing herpes zoster (HZ), whereas levels of anti-VZV antibodies do not correlate with HZ risk. This crucial role of VZV-specific cell-mediated immunity suggests that boosting these responses by vaccination will be an effective strategy for reducing the burden of HZ. Other strategies focus on preventing the major complication of HZ--post-herpetic neuralgia. These strategies include pre-emptive treatment with drugs such as tricyclic antidepressants, anticonvulsants and analgesics.
水痘带状疱疹病毒（VZV）特异性细胞免疫的损害，包括免疫衰老引起的损害，与带状疱疹（HZ）发病风险增加相关，而抗 VZV 抗体水平与 HZ 风险无关。VZV 特异性细胞免疫的这一关键作用表明，通过疫苗接种增强这些反应将是减少 HZ 负担的有效策略。其他策略侧重于预防 HZ 的主要并发症——带状疱疹后神经痛。这些策略包括预防性使用三环类抗抑郁药、抗惊厥药和镇痛药等药物进行治疗。
