University of Alabama at Birmingham, CHB 303, 1600-Seventh Avenue South, Birmingham, AL 35233, USA.
J Clin Virol. 2010 May;48 Suppl 1:S20-8. doi: 10.1016/S1386-6532(10)70005-6.
Herpes zoster (HZ; shingles)--a reactivation of the latent varicella zoster virus (VZV)--can cause significant morbidity. Its major complication is pain, particularly post-herpetic neuralgia (PHN). We will review the current management strategies available for the treatment of both acute HZ and PHN, including antiviral drugs, analgesic agents, anticonvulsants, tricyclic antidepressants and topical therapies. New molecules in development that show improved activity against VZV are also covered, and new drug targets are outlined. The role of translational neuroscience in moving towards a goal of finding disease-modifying treatments will be examined.
带状疱疹（HZ；带状疱疹）是潜伏的水痘带状疱疹病毒（VZV）的再激活，可导致显著的发病率。其主要并发症是疼痛，特别是带状疱疹后神经痛（PHN）。我们将回顾目前可用于治疗急性 HZ 和 PHN 的治疗策略，包括抗病毒药物、镇痛剂、抗惊厥药、三环类抗抑郁药和局部治疗。还涵盖了开发中显示出对 VZV 活性改善的新分子，并概述了新的药物靶点。将检查转化神经科学在朝着发现疾病修饰治疗目标的方向前进的作用。
