Garg S, Gupta S, Prakash K, Bhatnagar P
Lady Hardinge Medical College, New Delhi.
J Indian Med Assoc. 1991 Jan;89(1):6-9.
Clinical characteristics, ventilatory functions and serum immunoglobulins (IgG, IgM and IgA) were assessed in 30 asthmatic patients. Sixty per cent patients belonged to early onset group ie, had onset of disease before 30 years of age. Seasonal asthmatics formed the largest group (56.6%) followed by perennial (26.6%) and irregular (16.6%) type. On the basis of ventilatory function tests, maximum number of cases (15) had asthma of moderate severity, followed by mild (12 patients) and severe forms (3 patients). Mean serum levels (mg%) of IgG (1631.93 +/- 270.71) and IgM (233.82 +/- 86.93) were significantly elevated in asthmatics as compared to controls. Higher serum IgA levels were observed in bronchial asthma patients (257.58 +/- 81.06) as compared to controls (225.69 +/- 49.75), but this rise was not statistically significant. Duration, periodicity of asthmatic attacks and the severity had no influence on the levels of the above three mentioned immunoglobulins, but it was observed that patients who had associated other allergies and positive family history of atopic disorders exhibited higher serum IgA and IgM levels, compared to those who had no such history. This difference was however not seen in serum IgG levels.
对30例哮喘患者的临床特征、通气功能和血清免疫球蛋白（IgG、IgM和IgA）进行了评估。60%的患者属于早发型组，即发病年龄在30岁之前。季节性哮喘患者占比最大（56.6%），其次是常年性（26.6%）和间歇性（16.6%）类型。根据通气功能测试结果，大多数病例（15例）为中度哮喘，其次是轻度（12例）和重度（3例）。与对照组相比，哮喘患者的血清IgG（1631.93±270.71）和IgM（233.82±86.93）平均水平显著升高。与对照组（225.69±49.75）相比，支气管哮喘患者的血清IgA水平较高（257.58±81.06），但这种升高无统计学意义。哮喘发作的持续时间、周期性和严重程度对上述三种免疫球蛋白水平无影响，但观察到，与无此类病史的患者相比，患有其他过敏症且有特应性疾病家族史阳性的患者血清IgA和IgM水平较高。然而，血清IgG水平未观察到这种差异。
