Serum IgG, IgA and IgM in asthmatic children.

Serum levels of immunoglobulins G, A and M were determined in forty-five asthmatic children and in the same number of controls. Mean IgG and IgA levels in the asthmatics were not significantly different from those in the controls. Conversely, mean IgM values in female controls and all the controls taken as a group, were significantly higher than those in their asthmatic counterparts. There was no relationship between severity of asthma and the mean levels of the various immunoglobulins. However, the mean IgG value in asthmatic children with positive skin sensitivity tests was significantly higher than the mean value in those who had negative reactions. It is concluded that the serum levels of these immunoglobulins are of limited value in either the diagnosis of asthma or in the grading of its severity.