Laboratorio di Tecnologia Medica, Istituto Ortopedico Rizzoli, Italy.
Comput Methods Programs Biomed. 2011 Jun;102(3):227-37. doi: 10.1016/j.cmpb.2010.04.017. Epub 2010 May 26.
The introduction of integrative approaches to biomedical research (integrative biology, physiome, Virtual Physiological Human, etc.) poses original problems to computer aided medicine: the need to operate with large amounts of data that are strongly heterogeneous in structure, format and even in the knowledge domain that generated them; the need to integrate all of these data into a coherent whole; the further complication imposed by the fact that more and more frequently these data are captured at very different dimensional and/or temporal scales. The present study describes a first attempt at providing an interactive visualisation environment for homogeneous biomedical data defined over radically different spatial or temporal scales. In particular, we describe new strategies for the management of the dimensional information of highly heterogeneous data types; the management of temporal multiscaling; for 3D unstructured spatial multiscale visualisation and the related interaction paradigms and user interface. Preliminary results with a prototype implementation based on the OpenMAF application framework (http://www.openmaf.org) indicate that it is possible to develop effective environments for interactive visualisation of multiscale biomedical data.
综合方法在生物医学研究中的引入（综合生物学、生理系统、虚拟生理人等）给计算机辅助医学带来了一些新的问题：需要处理大量结构、格式甚至生成它们的知识领域都存在强烈异构性的数据；需要将所有这些数据集成到一个连贯的整体中；而越来越多的数据通常是在非常不同的维度和/或时间尺度上捕获的，这进一步增加了复杂性。本研究描述了首次尝试为在根本不同的空间或时间尺度上定义的同质生物医学数据提供交互可视化环境。特别是，我们描述了用于管理高度异构数据类型的维度信息的新策略；管理时间多尺度；用于 3D 非结构化空间多尺度可视化以及相关的交互范例和用户界面。基于 OpenMAF 应用程序框架（http://www.openmaf.org）的原型实现的初步结果表明，可以为多尺度生物医学数据的交互可视化开发有效的环境。
