一些新型 4(3H)-喹唑啉-2-甲酰基缩氨基硫脲的合成及其金属配合物的研究及其抗惊厥、镇痛、细胞毒性和抗菌活性的研究-第 1 部分。
Synthesis of some new 4(3H)-quinazolinone-2-carboxaldehyde thiosemicarbazones and their metal complexes and a study on their anticonvulsant, analgesic, cytotoxic and antimicrobial activities - part-1.
机构信息
Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt.
出版信息
Eur J Med Chem. 2010 Aug;45(8):3365-73. doi: 10.1016/j.ejmech.2010.04.020. Epub 2010 Apr 27.
Novel 3-aryl-4(3H)-quinazolinone-2-carboxaldehydes, their corresponding Schiff's base and thiosemicarbazone derivatives were synthesized from the starting 5-iodo anthranilic acid. Copper(II), zinc(II) complexes of some thiosemicarbazone derivatives were also synthesized and characterized. Screening for some selected compounds was carried out to probe their potential anticonvulsant, analgesic, cytotoxic as well as their antimicrobial activities.
新型 3-芳基-4(3H)-喹唑啉-2-甲酰醛、它们相应的席夫碱和缩氨基硫脲衍生物是由起始原料 5-碘邻氨基苯甲酸合成的。一些缩氨基硫脲衍生物的铜(II)、锌(II)配合物也被合成并进行了表征。对一些选定的化合物进行了筛选，以研究它们潜在的抗惊厥、镇痛、细胞毒性以及抗菌活性。
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