Department of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Center of Biomedical Sciences Research, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Molecules. 2021 Apr 15;26(8):2288. doi: 10.3390/molecules26082288.
Herein, we report the synthesis of eight new mononuclear and binuclear Co, Ni, Cu, and Zn methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining thiosemicarbazone complex with potent biological activity. The structure of the MTSC ligand and its metal complexes was fully characterized by elemental analysis, spectroscopic techniques (NMR, FTIR, UV-Vis), molar conductivity, thermogravimetric analysis (TG), and thermal differential analysis (DrTGA). The spectral and analytical data revealed that the obtained thiosemicarbazone-metal complexes have octahedral geometry around the metal center, except for the Zn-thiosemicarbazone complexes, which showed a tetrahedral geometry. The antibacterial and antifungal activities of the MTSC ligand and its (Co, Ni, Cu, and Zn) metal complexes were also investigated. Interestingly, the antibacterial activity of MTSC- metal complexes against examined bacteria was higher than that of the MTSC alone, which indicates that metal complexation improved the antibacterial activity of the parent ligand. Among different metal complexes, the MTSC- mono- and binuclear Cu complexes showed significant antibacterial activity against and , better than that of the standard gentamycin drug. The in silico molecular docking study has revealed that the MTSC ligand could be a potential inhibitor for the oxidoreductase protein.
本文报道了 8 种新型单核和双核 Co、Ni、Cu 和 Zn 甲氧基缩氨硫脲（MTSC）配合物的合成，旨在获得具有强生物活性的缩氨硫脲配合物。MTSC 配体及其金属配合物的结构通过元素分析、光谱技术（NMR、FTIR、UV-Vis）、摩尔电导率、热重分析（TG）和差热分析（DrTGA）进行了全面表征。光谱和分析数据表明，所得的缩氨硫脲-金属配合物在金属中心周围具有八面体几何形状，除了 Zn-缩氨硫脲配合物外，其呈现四面体几何形状。还研究了 MTSC 配体及其（Co、Ni、Cu 和 Zn）金属配合物的抗菌和抗真菌活性。有趣的是，MTSC-金属配合物对所检查细菌的抗菌活性高于单独的 MTSC，这表明金属络合提高了母体配体的抗菌活性。在不同的金属配合物中，MTSC-单核和双核 Cu 配合物对 和 表现出显著的抗菌活性，优于标准庆大霉素药物。计算机分子对接研究表明，MTSC 配体可能是氧化还原酶蛋白的潜在抑制剂。
