Singh Rabindra Pratap, Dhariwal Daljit, Bhujel Nabina, Shaikh Zarina, Davies Paul, Nishikawa Hiroshi, Solanki Guirish, Dover M S
Oral and Maxillofacial Surgery, Leeds General Infirmary, LS1 3EX, Leeds, UK.
Br J Oral Maxillofac Surg. 2010 Sep;48(6):438-42. doi: 10.1016/j.bjoms.2009.06.233. Epub 2010 May 26.
To try and identify potential parental risk factors for isolated non-syndromic metopic craniosynostosis, we did a telephone survey of parents of children who attended the craniofacial centre at Birmingham Children's Hospital (BCH), UK, from 1995 to 2004. We calculated the prevalence of a number of potential risk factors and compared them with those of the general population. A total of 103 children with syndromic or non-syndromic isolated metopic craniosynostosis were seen, of which 81 (79%) had non-syndromic, isolated metopic craniosynostosis (M:F ratio 3:1). The response rate to the telephone survey was 72%. The prevalences of maternal epilepsy and the use of valproate, antenatal maternal complications (hypertension or pre-eclampsia, haemorrhage, and urinary tract infection), and fertility treatment in our sample were significantly higher than among the general population (p=0.01 or less in all cases). The likely roles of maternal epilepsy and taking valproate in the aetiology of isolated non-syndromic metopic craniosynostosis are further consolidated by our study. The finding that antenatal complications are possible risk factors for craniosynostosis has not to our knowledge been published previously.
为了尝试确定孤立性非综合征性额缝早闭可能的父母风险因素，我们对1995年至2004年期间在英国伯明翰儿童医院（BCH）颅面中心就诊儿童的父母进行了电话调查。我们计算了一些潜在风险因素的患病率，并将其与普通人群的患病率进行比较。共诊治了103例患有综合征性或非综合征性孤立性额缝早闭的儿童，其中81例（79%）为非综合征性孤立性额缝早闭（男:女比例为3:1）。电话调查的回复率为72%。我们样本中母亲癫痫、丙戊酸盐使用、产前母亲并发症（高血压或先兆子痫、出血和尿路感染）以及生育治疗的患病率显著高于普通人群（所有情况p值均为0.01或更低）。我们的研究进一步证实了母亲癫痫和服用丙戊酸盐在孤立性非综合征性额缝早闭病因中的可能作用。据我们所知，产前并发症是颅缝早闭可能的风险因素这一发现此前尚未发表。
