Wust P, Nadobny J, Felix R, Deuflhard P, Louis A, John W
Department of Radiotherapy, Klinikum Rudolf Virchow of the Free University, Berlin, FRG.
Int J Hyperthermia. 1991 Jan-Feb;7(1):157-73. doi: 10.3109/02656739109004986.
A theoretical framework is presented for optimized heating of deep-seated tumours by phase and amplitude steering. The optimization problem for a specific tumour and perfusion case results in a functional dependency between power-level and maximum obtainable therapeutic efficiency. Different optimization criteria and strategies are outlined, which cause an increase of power or thermal dose in the tumour. Three tumour models (central pelvic tumour, eccentric abdominal tumour with or without necrosis) are analysed in detail. The simulation studies predict that appreciable parts of these tumours (50-100%) can be heated efficiently (42.5-43 degrees C) within the range of available and clinically tolerated power levels (1-5 kW/m), if tumour perfusion is less than 20-25 ml/100 g min. Some improvements are obtained by increasing the number of independent channels (from four to eight) and by the application of time-dependent (complementary) power-deposition patterns.
提出了一种通过相位和幅度控制实现深部肿瘤优化加热的理论框架。针对特定肿瘤和灌注情况的优化问题导致功率水平与可获得的最大治疗效率之间存在函数依赖关系。概述了不同的优化标准和策略，这些标准和策略会使肿瘤中的功率或热剂量增加。详细分析了三种肿瘤模型（中央盆腔肿瘤、有或无坏死的偏心腹部肿瘤）。模拟研究预测，如果肿瘤灌注小于20 - 25 ml/100 g min，在可用且临床可耐受的功率水平范围（1 - 5 kW/m）内，这些肿瘤的相当一部分（50 - 100%）能够被有效加热（42.5 - 43摄氏度）。通过增加独立通道数量（从四个增加到八个）以及应用随时间变化（互补）的功率沉积模式可获得一些改进。
