Gottlieb C F, Hagmann M J, Babij T M, Abitbol A A, Lewin A A, Houdek P V, Schwade J G
Department of Radiation Oncology, University of Miami School of Medicine, FL 33101.
Int J Hyperthermia. 1990 May-Jun;6(3):707-14. doi: 10.3109/02656739009140966.
Using microscopic techniques we have fabricated interstitial hyperthermia applicators having diameters of 0.20, 0.33 and 0.58 mm, which will fit through catheters of 30, 26 and 22 gauge, respectively. Existing commercial applicators having a diameter of 1.1 mm required 17 gauge (or larger) catheters. Our new applicators, which operate at 915 MHz, are a smaller version of a design used by others. We have characterized our applicators by determining the energy deposition patterns (SAR) in muscle-simulating phantoms. These patterns were determined by measuring the electric field intensity using a miniature implantable isotropic probe having a diameter of 3 mm. Contours of the SAR data for our applicators, as well as a larger commercial applicator, show that all of these applicators exhibit similar heating patterns. Test results suggest that the durability and power handling capability of our submillimetre applicators are adequate for use in patients. Our new applicators should be useful in the percutaneous treatment of deep-seated tumours, intraoperative treatments, and also permit intraluminal or intravascular access to tumours.
我们运用显微技术制作了直径分别为0.20、0.33和0.58毫米的组织间热疗施源器，它们分别可通过30号、26号和22号导管。现有的直径为1.1毫米的商用施源器需要17号（或更大号）的导管。我们新的施源器工作频率为915兆赫，是其他人所使用设计的缩小版。我们通过确定肌肉模拟体模中的能量沉积模式（比吸收率）来对施源器进行特性描述。这些模式是通过使用直径为3毫米的微型植入式各向同性探头测量电场强度来确定的。我们施源器以及一个更大的商用施源器的比吸收率数据等高线表明，所有这些施源器都呈现出相似的加热模式。测试结果表明，我们的亚毫米级施源器的耐用性和功率处理能力足以用于患者。我们的新施源器在深部肿瘤的经皮治疗、术中治疗中应该会很有用，并且还能实现对肿瘤的腔内或血管内介入。
