莫里斯肝癌5123tc和9121中血清白蛋白的合成与分泌。
The synthesis and secretion of serum albumin in Morris hepatomas 5123tc and 9121.
作者信息
Schreiber G, Urban J, Dryburgh H, Bradley T R
出版信息
Adv Exp Med Biol. 1977;92:565-82. doi: 10.1007/978-1-4615-8852-8_22.
In vivo, Morris hepatomas 5123tc and 9121 do not secrete serum proteins into the bloodstream. However, they synthesize albumin, at a reduced rate, if compared with liver. The produced albumin accumulates, leading to an enlargement of the Golgi apparatus and the appearance of intracellular vesicles. The proportion and the absolute amount of albumin found within the hepatoma cells is increased compared with liver. As described recently for liver in vivo and for hepatocyte suspensions, albumin is synthesized also in hepatoma cells via a precursor protein. Hepatoma cells in culture secrete albumin into the medium. However, albumin accumulates in the cells with time in culture, indicating again a limited secretory capacity of the hepatoma cell.
在体内，莫里斯肝癌5123tc和9121不会将血清蛋白分泌到血液中。然而，与肝脏相比，它们以较低的速率合成白蛋白。产生的白蛋白会积累，导致高尔基体增大和细胞内囊泡的出现。与肝脏相比，肝癌细胞内白蛋白的比例和绝对量都有所增加。正如最近在体内肝脏和肝细胞悬液中所描述的那样，肝癌细胞中白蛋白也是通过前体蛋白合成的。培养中的肝癌细胞会将白蛋白分泌到培养基中。然而，随着培养时间的延长，白蛋白会在细胞中积累，这再次表明肝癌细胞的分泌能力有限。
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