Department of Neurobiology, Harvard Medical School, Massachusetts Hall, Cambridge, MA 02138, USA.
Cell. 2010 May 28;141(5):752-4. doi: 10.1016/j.cell.2010.05.010.
Mice with mutations in the Hoxb8 gene exhibit compulsive grooming behavior. Chen et al. (2010) now report that this behavior stems from Hoxb8 deficiency in microglia, a type of immune cell in the brain derived from bone marrow. These findings provide intriguing connections between immune dysfunction and neuropsychiatric disorders.
携带 Hoxb8 基因突变的小鼠表现出强迫性梳理行为。Chen 等人（2010 年）现在报告称，这种行为源于大脑中一种源自骨髓的免疫细胞——小神经胶质细胞中的 Hoxb8 缺乏。这些发现为免疫功能障碍与神经精神疾病之间提供了有趣的联系。
