Department of Clinical Sciences, University of Agricultural Sciences, 750 07 Uppsala, Sweden.
Vet Rec. 2010 May 29;166(22):687-90. doi: 10.1136/vr.b4817.
This study investigated whether myocardial damage, as reflected by increased serum concentrations of cardiac-specific troponin I (cTnI), develops in dogs as a result of a bite from a common European viper (Vipera berus), and whether this damage occurs in the absence of clinically relevant ECG abnormalities. Twenty-four dogs presented following a snake bite were tested. On admission, and after 12, 24 and 36 hours, an ECG was recorded and serum was collected for analysis of cTnI from all the dogs. Thirteen dogs (54 per cent) had an undetectable serum cTnI concentration (<0.2 microg/l) and no abnormalities on ECG, five dogs (21 per cent) had increased serum concentrations of cTnI and no ECG abnormalities, six dogs (12.5 per cent) had increased cTnI concentrations and ECG abnormalities, and six dogs (12.5 per cent) had ECG abnormalities and undetectable cTnI concentrations. Only three dogs (12.5 per cent) had serum cTnI concentrations exceeding 1.0 microg/l at any time during the study. Evidence of myocardial cell damage was found in eight (32 per cent) of the 24 dogs. Cardiac arrhythmia was detected in three of these eight dogs.
本研究旨在探讨犬类是否会因被常见的欧洲蝰蛇（Vipera berus）咬伤而导致心肌损伤，这种损伤是否会在没有临床相关心电图异常的情况下发生，具体表现为血清中心脏特异性肌钙蛋白 I（cTnI）浓度升高。共有 24 只被蛇咬伤的犬接受了测试。所有犬在入院时以及 12、24 和 36 小时后记录心电图并采集血清，以分析 cTnI 浓度。13 只犬（54%）的血清 cTnI 浓度<0.2 μg/L，心电图无异常，5 只犬（21%）的 cTnI 浓度升高但心电图无异常，6 只犬（12.5%）的 cTnI 浓度升高且心电图异常，6 只犬（12.5%）的心电图异常但 cTnI 浓度不可测。在研究期间，只有 3 只犬（12.5%）的血清 cTnI 浓度在任何时候都超过 1.0 μg/L。24 只犬中，有 8 只（32%）存在心肌细胞损伤的证据。在这 8 只犬中，有 3 只存在心律失常。
