Muzyk Andrew, Gala Gary, Kahn David A
Department of Psychiatry, Columbia University College of Physicians and Surgeons, USA.
J Psychiatr Pract. 2010 Mar;16(2):125-8. doi: 10.1097/01.pra.0000369974.18274.e2.
Seizures can be a serious adverse effect of clozapine, often a last-resort antipsychotic with unique efficacy for some patients. Several anticonvulsants have been reported to be useful in preventing further clozapine-induced seizures and permitting continued treatment with this medication. The authors describe the first reported successful use of lamotrigine for this purpose.
癫痫发作可能是氯氮平的一种严重不良反应，氯氮平通常是一种对某些患者有独特疗效的抗精神病药物，往往是最后的治疗手段。据报道，几种抗惊厥药物可有效预防氯氮平进一步诱发癫痫发作，并使患者能够继续使用该药物进行治疗。作者描述了首次报道成功使用拉莫三嗪达到这一目的的案例。
