某些添加剂对盐酸四环素溶液光降解的影响。
Effect of certain additives on photodegradation of tetracycline hydrochloride solutions.
作者信息
Asker A F, Habib M J
机构信息
College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee.
出版信息
J Parenter Sci Technol. 1991 Mar-Apr;45(2):113-5.
The photostability of tetracycline hydrochloride solutions in the presence of selected potential stabilizers under various light sources was investigated. Reduced glutathione (GSH) demonstrated the greatest photostabilizing effect followed by p-aminobenzoic acid (PABA), ethylenediamine tetraacetic acid (EDTA) disodium salt, DL-cysteine, thiourea, sodium thiosulfate, and DL-methionine in a descending order. The photostabilizing effect of GSH was found to be dependent on its concentration, pH and buffer species of the medium, the light source, and the temperature of the solutions exposed to light.
研究了在各种光源下，盐酸四环素溶液在选定的潜在稳定剂存在时的光稳定性。还原型谷胱甘肽（GSH）表现出最大的光稳定作用，其次是对氨基苯甲酸（PABA）、乙二胺四乙酸（EDTA）二钠盐、DL-半胱氨酸、硫脲、硫代硫酸钠和DL-蛋氨酸，作用效果依次递减。发现GSH的光稳定作用取决于其浓度、介质的pH值和缓冲液种类、光源以及光照溶液的温度。
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