Habib M J, Asker A F
J Parenter Sci Technol. 1989 Nov-Dec;43(6):259-61.
p-Aminobenzoic acid (PABA), urocanic acid, and sodium urate were found to significantly enhance the photostability of doxorubicin hydrochloride [adriamycin, (ADR)]. d1-Methionine, thiourea, and glycine also increased the photostability of this drug, but to a lesser degree. Sodium thiosulfate on the other hand, was found to be detrimental to the photostability of ADR. The photostabilizing effect of PABA was found to increase with increase of its concentration and was influenced by the pH and the buffer species of the vehicle. The findings would have an impact on the enhancement of therapeutic efficacy of adriamycin when administered during radiation therapy.
对氨基苯甲酸（PABA）、尿刊酸和尿酸钠被发现能显著提高盐酸多柔比星[阿霉素，（ADR）]的光稳定性。d1-蛋氨酸、硫脲和甘氨酸也能提高这种药物的光稳定性，但程度较小。另一方面，发现硫代硫酸钠对阿霉素的光稳定性有害。发现PABA的光稳定作用随其浓度的增加而增强，并受载体的pH值和缓冲剂种类的影响。这些发现将对放射治疗期间给予阿霉素时提高其治疗效果产生影响。
