Dipartimento di Chimica Organica A. Mangini, Università di Bologna, Viale Risorgimento 4, 40136 Bologna, Italy.
Chem Asian J. 2010 Jul 5;5(7):1652-6. doi: 10.1002/asia.201000040.
The first catalytic method for the asymmetric aziridination of cyclic enones is described. The presented organocatalytic strategy is based on the use of an easily available organocatalyst that is able to convert a wide range of cyclic enones into the desired aziridines with very high enantiomeric purity and good chemical yield. Such a method may very well open up new opportunities to stereoselectively prepare complex chiral molecules that possess an indane moiety, a framework that is found in a large number of bioactive and pharmaceutically important molecules.
首次描述了一种不对称环烯酮氮丙啶化的催化方法。所提出的有机催化策略基于使用一种易得的有机催化剂，该催化剂能够将广泛的环烯酮转化为具有非常高对映纯度和良好化学收率的所需氮丙啶。这种方法很可能为立体选择性制备具有茚烷部分的复杂手性分子开辟新的机会，茚烷是许多生物活性和药物重要分子的骨架。
