Hepatic AAV gene transfer and the immune system: friends or foes?
作者信息
Herzog Roland W
机构信息
Department of Pediatrics, Division of Cellular and Molecular Therapy and Powell Gene Therapy Center, University of Florida, Gainesville, Florida 32610, USA.
出版信息
Mol Ther. 2010 Jun;18(6):1063-6. doi: 10.1038/mt.2010.96.
Abstract
摘要
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The pleiotropic effects of natural AAV infections on liver-directed gene transfer in macaques.天然 AAV 感染对食蟹猴肝脏靶向基因转移的多效性影响。
Mol Ther. 2010 Jan;18(1):126-34. doi: 10.1038/mt.2009.245. Epub 2009 Nov 3.
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Immunomodulatory gene therapy prevents antibody formation and lethal hypersensitivity reactions in murine pompe disease.免疫调节基因治疗可预防小鼠庞贝病的抗体形成和致死性超敏反应。
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Adeno-associated virus-mediated gene transfer to nonhuman primate liver can elicit destructive transgene-specific T cell responses.腺相关病毒介导的基因转移至非人灵长类动物肝脏可引发具有破坏性的转基因特异性T细胞反应。
Hum Gene Ther. 2009 Sep;20(9):930-42. doi: 10.1089/hum.2009.060.
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Capsid antigen presentation flags human hepatocytes for destruction after transduction by adeno-associated viral vectors.衣壳抗原呈递标记人类肝细胞，使其在被腺相关病毒载体转导后遭到破坏。
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