在转录延伸过程中核小体是如何被破坏的？
How are nucleosomes disrupted during transcription elongation?
作者信息
Zlatanova Jordanka, Victor Jean-Marc
出版信息
HFSP J. 2009 Dec;3(6):373-8. doi: 10.2976/1.3249971. Epub 2009 Nov 12.
Abstract
Chromatin structure is a powerful tool to regulate eukaryotic transcription. Moreover, nucleosomes are constantly remodeled, disassembled, and reassembled in the body of transcribed genes. Here we propose a general model that explains, in quantitative terms, how transcription elongation affects nucleosome structure at a distance as a result of the positive torque the polymerases create as they translocate along DNA templates.
摘要
染色质结构是调控真核生物转录的有力工具。此外，核小体在转录基因体内不断地重塑、解体和重新组装。在此，我们提出一个通用模型，从定量角度解释转录延伸如何由于聚合酶沿DNA模板移位时产生的正扭矩而在一定距离外影响核小体结构。
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