Barbi Maria, Mozziconacci Julien, Wong Hua, Victor Jean-Marc
Laboratoire de Physique Théorique de la Matière Condensée, CNRS UMR 7600, and CNRS GDR 3536, Université Pierre et Marie Curie, Case courrier 121, 4 place Jussieu, 75252 , Paris, France,
J Math Biol. 2014 Jan;68(1-2):145-79. doi: 10.1007/s00285-012-0621-y. Epub 2012 Nov 20.
Using a simple geometric model, we propose a general method for computing the linking number of the DNA embedded in chromatin fibers. The relevance of the method is reviewed through the single molecule experiments that have been performed in vitro with magnetic tweezers. We compute the linking number of the DNA in the manifold conformational states of the nucleosome which have been evidenced in these experiments and discuss the functional dynamics of chromosomes in the light of these manifold states.
利用一个简单的几何模型，我们提出了一种计算嵌入染色质纤维中DNA的连环数的通用方法。通过使用磁镊在体外进行的单分子实验，对该方法的相关性进行了综述。我们计算了在这些实验中已得到证实的核小体多种构象状态下DNA的连环数，并根据这些多种状态讨论了染色体的功能动力学。
