Department of Neurology, University of Duisburg-Essen, Germany.
Curr Pain Headache Rep. 2010 Aug;14(4):316-20. doi: 10.1007/s11916-010-0126-6.
Pain, including headache, is a frequent complaint of individuals with multiple sclerosis (MS). Prevalence of headache in patients with MS was reported to be higher than 50%, but it is uncertain if this is different than what is seen in the general population. Nonetheless, it is possible that MS and headaches are comorbid. Case reports illustrated that isolated MS lesions (eg, in "strategic" regions like the midbrain) may cause severe headaches often resembling migraine. Furthermore, the role of MS disease-modifying agents needs to be taken into consideration. Mode of action and side effect profiles differ, and treatment per se may sometimes trigger headache in patients with MS. Thorough evaluation of headache in patients with MS is crucial to optimize patient management to help improve quality of life.
疼痛，包括头痛，是多发性硬化症（MS）患者常见的主诉。据报道，MS 患者头痛的患病率高于 50%，但尚不确定这是否与普通人群不同。尽管如此，MS 和头痛可能是共病的。病例报告表明，孤立的 MS 病变（例如，在中脑等“战略”区域）可能导致类似偏头痛的剧烈头痛。此外，还需要考虑 MS 疾病修正治疗药物的作用。作用机制和副作用谱不同，而且治疗本身有时可能会引发 MS 患者的头痛。对 MS 患者头痛进行彻底评估对于优化患者管理以帮助提高生活质量至关重要。
