Gironell Alexandre, Vives Bàrbara, Pagonabarraga Javier
Unidad de Trastornos del Movimiento, Servicio de Neurología, Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, España.
Rev Neurol. 2010 Jun 1;50(11):676-84.
Head tremor, either as an isolated symptom or as part of a symptomatic complex, occurs in patients with different neurological diseases. Little research has been carried out to analyse the clinical features of this neurological symptom.
To review the symptomatology, aetiology and therapeutics of brain tremors.
Two main types of brain tremor can be distinguished: tremor of the whole brain (holocephalic tremor) and segmented brain tremor (tremor of the jaw, tongue, chin, soft palate, task-specific, orthostatic orolingual and undetermined). Essential tremor, the main cause of brain tremor, and dystonic tremor give rise to holocephalic-type tremor in the vast majority of cases. Brain tremor in Parkinsonism is characteristically of the segmented type. The effectiveness of the pharmacological treatment of brain tremor is very limited. Botulinum toxin is a promising therapy for brain tremors of any causation. In severe cases of brain tremor, functional surgery by means of deep brain stimulation of the intermediate ventral thalamic nucleus is useful, but must be performed bilaterally.
The semiological characteristics of brain tremor are a valuable aid in the aetiological diagnosis. Pharmacological therapy is very limited. Botulinum toxin and functional surgery of the intermediate ventral thalamic nucleus are useful in selected patients.
头部震颤,无论是作为孤立症状还是作为症状复合体的一部分,都发生在患有不同神经系统疾病的患者中。针对这一神经症状的临床特征开展的研究很少。
综述脑部震颤的症状学、病因学和治疗方法。
脑部震颤可分为两种主要类型:全脑震颤(holocephalic tremor)和节段性脑部震颤(下颌、舌头、下巴、软腭、特定任务性、体位性口舌震颤及未明确类型的震颤)。原发性震颤是脑部震颤的主要病因,在绝大多数情况下,原发性震颤和肌张力障碍性震颤会引发全脑型震颤。帕金森病中的脑部震颤典型表现为节段性类型。脑部震颤的药物治疗效果非常有限。肉毒杆菌毒素对任何病因引起的脑部震颤都是一种有前景的治疗方法。在严重的脑部震颤病例中,通过对丘脑腹中间核进行深部脑刺激的功能性手术是有效的,但必须双侧进行。
脑部震颤的症状学特征对病因诊断有重要帮助。药物治疗效果非常有限。肉毒杆菌毒素和丘脑腹中间核功能性手术对部分患者有效。