Hsu Yaw-Don
Neurology Department, National Defense Medical Center & Tri-Service General Hospital.
Acta Neurol Taiwan. 2010 Mar;19(1):62-9.
Tremor is the most common involuntary movement disorder. It can be an isolated symptom or a symptom of another neurological disorder, such as dystonia, Parkinson disease, spinocerebellar ataxia et al. It is an unintentional, somewhat rhythmic, muscle movement involving to-and-fro movements of one or more parts of the body. It can affect the hands, arms, head, vocal cord, jaw, chin, and legs. Most tremors occur in the hands. Clinically, the most useful way to categorized tremor is whether it occurs mainly at rest, on postural, or during movement (kinetic tremor). Tremor is most common classified by different clinical features and cause or origin; include essential tremor, Parkinsonian tremor, cerebellar tremor, dystonic tremor, orthostatic tremor, physiologic tremor, and psychogenic tremor. Diagnosis need a detail history (include familial inheritance, drugs exposure, alcohol consumption or withdraw); complete physical examination and laboratory tests. Electromyography is also a simple and quick method with which to calculate tremor frequency and amplitude for assisting diagnosis. Treatment for majority of tremor syndrome is purely symptomatic, and is similar regardless of the underlying cause of the tremor. There are different medicines to try in order propranolol, clonazepam, primidome and gabapentin for limb tremors, or trihexyphenidyl for dystonic tremor. Focal botulinum toxin injection may be help in focal tremor. Neurosurgery is only indicated in severe tremor, such as deep brain stimulation (DBS) of subthalamic nucleus for primary or secondary parkinsonian tremor.
震颤是最常见的非自愿运动障碍。它可以是一种孤立的症状,也可以是其他神经系统疾病的症状,如肌张力障碍、帕金森病、脊髓小脑共济失调等。它是一种无意的、有点有节奏的肌肉运动,涉及身体一个或多个部位的来回运动。它可影响手、臂、头、声带、颌、下巴和腿。大多数震颤发生在手部。临床上,对震颤进行分类最有用的方法是看它主要是在休息时、姿势性时还是运动时(动作性震颤)出现。震颤最常根据不同的临床特征和病因或起源进行分类;包括特发性震颤、帕金森震颤、小脑性震颤、肌张力障碍性震颤、直立性震颤、生理性震颤和心因性震颤。诊断需要详细的病史(包括家族遗传、药物接触、饮酒或戒酒情况);全面的体格检查和实验室检查。肌电图也是一种简单快速的方法,可用于计算震颤频率和幅度以辅助诊断。大多数震颤综合征的治疗纯粹是对症治疗,无论震颤的潜在病因如何,治疗方法都相似。有不同的药物可供尝试,如用于肢体震颤的普萘洛尔、氯硝西泮、扑米酮和加巴喷丁,或用于肌张力障碍性震颤的苯海索。局部肉毒杆菌毒素注射可能有助于治疗局部震颤。神经外科手术仅适用于严重震颤,如用于原发性或继发性帕金森震颤的丘脑底核深部脑刺激(DBS)。