Petersson Fredrik, Tang Aymeric Lim Yu, Jin Andre Cheah Eu, Barr Ronald J, Lee Victor K
Department of Pathology, National University Health System, Singapore.
Am J Dermatopathol. 2010 Jun;32(4):387-91. doi: 10.1097/dad.0b013e3181c03402.
We herein present the clinicopathological features of an atypical cellular unguioblastic fibroma, a rare onychomatrical tumor, in an adult woman of Southeast Asian origin. The tumor displayed both diffuse hypercellularity and atypia in the mesenchymal component and the presence of large multinucleated cells with a ring-/floret-like arrangement of irregular and hyperchromatic nuclei. The mesenchymal cells displayed a patchy weak positive immunereactivity for CD34 (including atypical and wreath-like multinucleated cells) and for CD10 but were negative for low molecular weight cytokeratins, epithelial membrane antigen, CD68, factor XIIIa, smooth muscle actin, desmin, and HMB-45. The proliferative index as measured immunohistochemically (Mib-1/Ki-67) was 5%. The extent of these atypical histological features has not previously been described. One-year follow-up has been uneventful.
我们在此报告一例非典型细胞性甲床成纤维细胞瘤的临床病理特征，该肿瘤为罕见的甲床肿瘤，发生于一名东南亚裔成年女性。肿瘤在间充质成分中表现出弥漫性细胞增多和异型性，存在大的多核细胞，其核呈不规则和深染，呈环状/花环状排列。间充质细胞对CD34（包括非典型和花环样多核细胞）和CD10呈斑片状弱阳性免疫反应，但对低分子量细胞角蛋白、上皮膜抗原、CD68、因子 XIIIa、平滑肌肌动蛋白、结蛋白和HMB-45呈阴性。免疫组化测定的增殖指数（Mib-1/Ki-67）为5%。这些非典型组织学特征的程度此前尚未见报道。一年的随访情况良好。
