[浅表性肢端纤维黏液瘤：三例]
[Superficial acral fibromyxoma: three cases].
作者信息
Cogrel O, Stanislas S, Coindre J-M, Guillot P, Beylot-Barry M, Doutre M-S, Vergier B
机构信息
Service de Dermatologie, Hôpital Haut-Lévêque, CHU de Bordeaux, avenue de Magellan, 33604 Pessac Cedex, France.
出版信息
Ann Dermatol Venereol. 2010 Dec;137(12):789-93. doi: 10.1016/j.annder.2010.08.003.
BACKGROUND
in this report of three new cases of superficial acral fibromyxoma (SAF), we discuss the clinicopathological features of this acral fibrous tumour as well as the differential diagnoses for hard nodules affecting the extremities.
PATIENTS AND METHODS
these three lesions involved the standard presentation of a large solitary flesh coloured nodule causing deformation of a toenail or a fingernail. Biopsy showed the presence within a fibromyxoid tumour of proliferating fusiform cells having no atypical features and expressing CD 34 diffusely, and in more focal and less consistent fashion, epithelial membrane antigen (EMA) and CD 99. FISH testing for translocation t(17; 22) proved negative.
DISCUSSION
this fairly common acral fibrous tumour is poorly known and in certain cases histology results may suggest myxoid dermatofibrosarcoma, which carries a completely different prognosis.
背景
在这份关于3例浅表性肢端纤维黏液瘤（SAF）新病例的报告中，我们讨论了这种肢端纤维性肿瘤的临床病理特征以及影响四肢的硬性结节的鉴别诊断。
患者与方法
这3个病变均表现为典型的单个大的肉色结节，导致趾甲或指甲变形。活检显示在纤维黏液样肿瘤内存在增殖的梭形细胞，这些细胞无非典型特征，弥漫性表达CD 34，且以更局灶性和不太一致的方式表达上皮膜抗原（EMA）和CD 99。针对易位t(17; 22)的荧光原位杂交（FISH）检测结果为阴性。
讨论
这种相当常见的肢端纤维性肿瘤鲜为人知，在某些情况下，组织学结果可能提示黏液样皮肤纤维肉瘤，而后者的预后完全不同。
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