Ksiazek Piotr, Makara-Studzińska Marta, Załuska Alicja, Kaim Renata, Załuska Wojciech
Katedra i Zakład Zdrowia Publicznego, Uniwersytetu Medycznego w Lublinie.
Przegl Lek. 2009;66(12):1036-9.
Depression is the most common psychological problem encountered among patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD) and is associated with increased morbidity and mortality in these patients. Chronic inflammation is known to play an important role in the pathophysiology of depression, and levels of proinflammatory cytokines are increased in chronic renal failure (CRF) patients. The objective of this study was to examine the prevalence and degree of depression as measured using Beck Depression Inventory (BDI) in relation with nutrition, inflammation and biochemical dialysis adequacy parameters.
200 healthy volunteers and 206 patients on hemodialysis were enrolled in this study. Depressive symptoms were measured with the Beck Depression Inventory (BDI).
Medium and moderate stage of depression symptoms occurred in 70% of HD patients. Serum CRP levels were significantly different among HD patients with medium and moderate stage of depressive symptoms.
抑郁症是慢性肾脏病（CKD）和终末期肾病（ESRD）患者中最常见的心理问题，并且与这些患者发病率和死亡率的增加相关。已知慢性炎症在抑郁症的病理生理学中起重要作用，并且在慢性肾衰竭（CRF）患者中促炎细胞因子水平升高。本研究的目的是使用贝克抑郁量表（BDI）来检查抑郁症的患病率和程度，并将其与营养、炎症和生化透析充分性参数相关联。
本研究纳入了200名健康志愿者和206名接受血液透析的患者。使用贝克抑郁量表（BDI）测量抑郁症状。
70%的血液透析患者出现中度和中度抑郁症状。血清CRP水平在有中度和中度抑郁症状的血液透析患者中存在显著差异。
