Laboratory of Clinical Neuroscience, Postgraduate Program in Health and Behavior, Center for Life Sciences and Health, Pelotas, Brazil.
Psychiatry Clin Neurosci. 2014 Apr;68(4):275-82. doi: 10.1111/pcn.12130. Epub 2013 Dec 25.
In hemodialysis patients, depression appears as the most common psychopathological condition. States of advanced chronic kidney disease and dialysis are associated with a state of chronic inflammation. Depression has been linked to activation of the immune system characterized by high levels of pro-inflammatory cytokines. In this study, we investigated the possible correlations between depression, and interleukin-6 (IL-6) in hemodialysis patients.
Seventy-five hemodialysis patients were enrolled in a cross-sectional study from September to November 2011 in Pelotas, Rio Grande do Sul. Demographic data were obtained from a questionnaire and the Beck Depression Inventory (BDI) was used to determine the presence or absence of depression symptoms. Biochemical parameters, dialysisdosage delivery, and IL-6 serum levels were measured.
Prevalence of depression among hemodialysis patients was 48% (BDI ≥ 14). In biochemical assessments, depressed patients showed a decrease in urea (P = 0.01) and increase of IL-6 (P = 0.04) levels. The correlation analysis between BDI scores and the biochemical variables showed that BDI was negatively correlated with urea (P = 0.03) and potassium (P = 0.04), but not with IL-6 levels.
Hemodialysis patients with depression showed higher levels of IL-6 but the severity of depressive symptoms was not correlated with levels of this cytokine.
在血液透析患者中，抑郁是最常见的精神病理学表现。晚期慢性肾脏病和透析状态与慢性炎症状态相关。抑郁与以促炎细胞因子水平升高为特征的免疫系统激活有关。本研究旨在调查血液透析患者的抑郁与白细胞介素-6（IL-6）之间可能存在的相关性。
2011 年 9 月至 11 月，在南里奥格兰德州佩洛塔斯，我们对 75 名血液透析患者进行了横断面研究。问卷调查获取人口统计学数据，贝克抑郁量表（BDI）用于确定是否存在抑郁症状。测定生化参数、透析剂量和血清 IL-6 水平。
血液透析患者的抑郁患病率为 48%（BDI≥14）。在生化评估中，抑郁患者的尿素（P=0.01）水平降低，IL-6（P=0.04）水平升高。BDI 评分与生化变量之间的相关性分析表明，BDI 与尿素（P=0.03）和钾（P=0.04）呈负相关，但与 IL-6 水平无关。
伴抑郁的血液透析患者的 IL-6 水平较高，但抑郁症状的严重程度与该细胞因子的水平无关。
