散发性 Creutzfeldt-Jakob 病伴脑干受累患者的中枢性睡眠呼吸暂停。

Central apnea in a sporadic case of Creutzfeldt-Jakob disease with brainstem involvement.

机构信息

Unitat de Diagnòstic i Tractament de les Demències, Neurology Service, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain.

出版信息

Acta Neurol Belg. 2010 Mar;110(1):113-5.

PMID:20514939

Abstract

We report a patient with Creutzfeldt-Jakob disease with somnolence as an initial manifestation and sleep apneas as a prominent sign. A respiratory polygraphy revealed the presence of a continuous Cheyne-Stokes pattern both awake and during sleep with central apneas. The neuropathology showed PrP deposition in brainstem involving respiratory nuclei. Central apnea is a rare manifestation of CJD that can be observed from early stages and may be related with PrP deposition in brainstem structures.

摘要

我们报告了一例以嗜睡为初始表现和睡眠呼吸暂停为突出表现的克雅氏病患者。呼吸描记法显示，无论是在清醒状态还是睡眠状态，都存在连续的 Cheyne-Stokes 模式和中枢性呼吸暂停。神经病理学显示脑干呼吸核中存在 PrP 沉积。中枢性呼吸暂停是 CJD 的一种罕见表现，可从早期观察到，可能与脑干结构中 PrP 沉积有关。