Vendrame Martina, Jackson Stephanie, Syed Sana, Kothare Sanjeev V, Auerbach Sanford H
Neurology Department, C-3, Boston University, 72 E Concord Street, Boston, MA, 02118, USA,
Sleep Breath. 2014 Mar;18(1):119-24. doi: 10.1007/s11325-013-0858-8. Epub 2013 May 1.
We sought to examine the prevalence of central sleep apnea (CSA) and complex sleep apnea (CompSA) in patients with epilepsy and to examine their clinical profile, with respect to epilepsy type, etiology, medication use, and EEG abnormalities.
We undertook a retrospective analysis of 719 consecutive patients with epilepsy who underwent polysomnography (PSG) at our institution between 2004 and 2011. Of the 458 patients with complete data, we excluded 42 patients with congestive heart failure or left ventricular ejection fraction <40 %. Comparison of clinical and PSG variables between the three groups were conducted with Fisher exact test and analysis of variance.
Out of 416 patients tested, 315 (75 %) had obstructive sleep apnea (OSA), 16 (3.7 %) had CSA, 33 (7.9 %) had CompSA. There were more males in the CSA and CompSA groups than in the OSA group (81.2, 81.8, and 59.6 %, respectively, p=0.04). Focal seizures were more prevalent in patients with CSA than in patients OSA or CompSA (62.5, 265, and 21.1 %, respectively, p=0.02).
About 11 % of epilepsy patients have sleep-breathing disorders with central apneas, which is not higher than that in a general population. These data should be expanded with future research investigating the role of interictal, ictal, and postictal central apneas in epileptogenesis and epilepsy.
我们试图研究癫痫患者中枢性睡眠呼吸暂停（CSA）和复杂性睡眠呼吸暂停（CompSA）的患病率，并根据癫痫类型、病因、药物使用情况和脑电图异常来研究其临床特征。
我们对2004年至2011年间在我们机构接受多导睡眠图（PSG）检查的719例连续癫痫患者进行了回顾性分析。在458例有完整数据的患者中，我们排除了42例充血性心力衰竭或左心室射血分数<40%的患者。采用Fisher精确检验和方差分析对三组患者的临床和PSG变量进行比较。
在416例接受测试的患者中，315例（75%）患有阻塞性睡眠呼吸暂停（OSA），16例（3.7%）患有CSA，33例（7.9%）患有CompSA。CSA组和CompSA组的男性患者多于OSA组（分别为81.2%、81.8%和59.6%，p=0.04）。CSA患者的局灶性癫痫发作比OSA或CompSA患者更常见（分别为62.5%、26.5%和21.1%，p=0.02）。
约11%的癫痫患者存在伴有中枢性呼吸暂停的睡眠呼吸障碍，这并不高于普通人群。这些数据应通过未来研究发作间期、发作期和发作后期中枢性呼吸暂停在癫痫发生和癫痫中的作用来进一步扩充。
